http://www.immuquest.com//rss/latest_products/en The Latest products from Immuquest Copyright 2012 Immuquest en Wed, 22 Feb 2012 13:06:06 +0000 Wed, 22 Feb 2012 13:06:06 +0000 Wed, 22 Feb 2012 13:03:13 +0000 <a href="http://www.immuquest.com/tags-cell-markers-c212/fusion-marker-proteins-c213/nesprin1-antibody-mouse-anti-nesprin1-p1098"><img src="http://www.immuquest.com/images/products/thumbnails/1329915790-51088100.jpg" alt="Nesprin1 Antibody - Mouse Anti-Nesprin1" /></a> <p><a href="http://www.immuquest.com/tags-cell-markers-c212/fusion-marker-proteins-c213/nesprin1-antibody-mouse-anti-nesprin1-p1098">Nesprin1 Antibody - Mouse Anti-Nesprin1</a></p> <p><p>There are two genes encoding members of a new family of type II integral membrane proteins. Both are ubiquitously expressed, and tissue-specific alternative mRNA initiation and splicing generate at least two major isoforms of each protein, with the smaller isoforms being truncated at the N-terminus.These proteins are called Nesprin l and 2 for nuclear envelope spectrin repeat, as they are characterized by the presence of multiple, clustered spectrin repeats, bipartite nuclear localization sequences and a conserved C-terminal, single transmembrane domain. Transient transfection of EGFP-fusion expression constructs demonstrated their localization to the nuclear membrane with a novel C-terminal, TM domain-containing sequence essential for perinuclear localization. Nesprin l is developmentally regulated in both smooth and skeletal muscle and is relocalized from the nuclear envelope to the nucleus and cytoplasm during C2Cl2 myoblast differentiation. Nesprins may function as &quot;dystrophins of the nucleus&quot; to maintain nuclear organization and structural integrity. There are several different isoforms</p></p> http://www.immuquest.com/tags-cell-markers-c212/fusion-marker-proteins-c213/nesprin1-antibody-mouse-anti-nesprin1-p1098 http://www.immuquest.com/tags-cell-markers-c212/fusion-marker-proteins-c213/nesprin1-antibody-mouse-anti-nesprin1-p1098 Wed, 22 Feb 2012 13:06:06 +0000 <a href="http://www.immuquest.com/signal-transduction-c37/lamins-c141/emerin-antibody-mouse-anti-emerin-p1097"><img src="http://www.immuquest.com/images/products/thumbnails/1329915904-04090700.jpg" alt="Emerin Antibody - Mouse Anti-Emerin" /></a> <p><a href="http://www.immuquest.com/signal-transduction-c37/lamins-c141/emerin-antibody-mouse-anti-emerin-p1097">Emerin Antibody - Mouse Anti-Emerin</a></p> <p><p>Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C</p></p> http://www.immuquest.com/signal-transduction-c37/lamins-c141/emerin-antibody-mouse-anti-emerin-p1097 http://www.immuquest.com/signal-transduction-c37/lamins-c141/emerin-antibody-mouse-anti-emerin-p1097 Tue, 31 Jan 2012 12:09:59 +0000 <a href="http://www.immuquest.com/sub-cellular-markers-c39/nuclear-envelope-c153/nesprin2-antibody-mouse-anti-nesprin2-p1096"><img src="http://www.immuquest.com/images/products/thumbnails/1327498550-33070600.jpg" alt="Nesprin2 Antibody - Mouse Anti-Nesprin2" /></a> <p><a href="http://www.immuquest.com/sub-cellular-markers-c39/nuclear-envelope-c153/nesprin2-antibody-mouse-anti-nesprin2-p1096">Nesprin2 Antibody - Mouse Anti-Nesprin2</a></p> <p><p>Nesprin 2 is involved in the maintenance of nuclear organization and structural integrity. It interacts with the nuclear envelope and with F-actin in the cytoplasm, thereby connecting nuclei to the cytoskeleton</p></p> http://www.immuquest.com/sub-cellular-markers-c39/nuclear-envelope-c153/nesprin2-antibody-mouse-anti-nesprin2-p1096 http://www.immuquest.com/sub-cellular-markers-c39/nuclear-envelope-c153/nesprin2-antibody-mouse-anti-nesprin2-p1096 Wed, 25 Jan 2012 13:33:41 +0000 <a href="http://www.immuquest.com/sub-cellular-markers-c39/nuclear-envelope-c153/sun2-antibody-rabbit-anti-sun2-p1095"><img src="http://www.immuquest.com/images/products/thumbnails/1327495621-10955400.jpg" alt="SUN2 Antibody ; Rabbit Anti-SUN2" /></a> <p><a href="http://www.immuquest.com/sub-cellular-markers-c39/nuclear-envelope-c153/sun2-antibody-rabbit-anti-sun2-p1095">SUN2 Antibody ; Rabbit Anti-SUN2</a></p> <p><p>SUN proteins form part of the LINC complex - a protein bridge that spans the nuclear envelope linking the nucleoskeleten to the actin cytoskeleten. They are located on the inner nuclear membrane side of the complex. The LINC complex is thought to function in controlling nuclear position, contributing to mechanical resistance and the overall architecture of the cell. SUN2 can exist in a heterodimer with SUN1. Both can interact with lamins and nesprins in the nuclear envelope</p></p> http://www.immuquest.com/sub-cellular-markers-c39/nuclear-envelope-c153/sun2-antibody-rabbit-anti-sun2-p1095 http://www.immuquest.com/sub-cellular-markers-c39/nuclear-envelope-c153/sun2-antibody-rabbit-anti-sun2-p1095 Wed, 25 Jan 2012 13:33:41 +0000 <a href="http://www.immuquest.com/epigenetics-c31/chromatin-c105/sun1-antibody-rabbit-anti-sun1-p1094"><img src="http://www.immuquest.com/images/products/thumbnails/1327494443-69637500.jpg" alt="SUN1 Antibody - Rabbit Anti-SUN1" /></a> <p><a href="http://www.immuquest.com/epigenetics-c31/chromatin-c105/sun1-antibody-rabbit-anti-sun1-p1094">SUN1 Antibody - Rabbit Anti-SUN1</a></p> <p><p>Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs)</p></p> http://www.immuquest.com/epigenetics-c31/chromatin-c105/sun1-antibody-rabbit-anti-sun1-p1094 http://www.immuquest.com/epigenetics-c31/chromatin-c105/sun1-antibody-rabbit-anti-sun1-p1094 Wed, 25 Jan 2012 13:33:41 +0000 <a href="http://www.immuquest.com/nuclear-signalling-c35/nuclear-envelope-c126/nesprin2-antibody-rabbit-anti-nesprin2-p1093"><img src="http://www.immuquest.com/images/products/thumbnails/1327493240-70729800.jpg" alt="Nesprin2 Antibody - Rabbit Anti-Nesprin2" /></a> <p><a href="http://www.immuquest.com/nuclear-signalling-c35/nuclear-envelope-c126/nesprin2-antibody-rabbit-anti-nesprin2-p1093">Nesprin2 Antibody - Rabbit Anti-Nesprin2</a></p> <p><p>Nesprin 2 is involved in the maintenance of nuclear organization and structural integrity. It interacts with the nuclear envelope and with F-actin in the cytoplasm, thereby connecting nuclei to the cytoskeleton</p></p> http://www.immuquest.com/nuclear-signalling-c35/nuclear-envelope-c126/nesprin2-antibody-rabbit-anti-nesprin2-p1093 http://www.immuquest.com/nuclear-signalling-c35/nuclear-envelope-c126/nesprin2-antibody-rabbit-anti-nesprin2-p1093 Wed, 25 Jan 2012 13:33:41 +0000 <a href="http://www.immuquest.com/nuclear-signalling-c35/nuclear-envelope-c126/nesprin3-antibody-rabbit-anti-nesprin3-p1092"><img src="http://www.immuquest.com/images/products/thumbnails/1327491752-51456100.jpg" alt="Nesprin3 Antibody - Rabbit Anti-Nesprin3 " /></a> <p><a href="http://www.immuquest.com/nuclear-signalling-c35/nuclear-envelope-c126/nesprin3-antibody-rabbit-anti-nesprin3-p1092">Nesprin3 Antibody - Rabbit Anti-Nesprin3 </a></p> <p><p>Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system</p></p> http://www.immuquest.com/nuclear-signalling-c35/nuclear-envelope-c126/nesprin3-antibody-rabbit-anti-nesprin3-p1092 http://www.immuquest.com/nuclear-signalling-c35/nuclear-envelope-c126/nesprin3-antibody-rabbit-anti-nesprin3-p1092 Wed, 25 Jan 2012 13:33:41 +0000 <a href="http://www.immuquest.com/tags-cell-markers-c212/fusion-marker-proteins-c213/glutathione-s-transferase-gst-antibody-mouse-anti-glutathione-s-transferase-gst-p1091"><img src="http://www.immuquest.com/images/products/thumbnails/1320151987-14015800.jpg" alt="Glutathione S-transferase (GST) antibody ; Mouse Anti-Glutathione S-transferase (GST)" /></a> <p><a href="http://www.immuquest.com/tags-cell-markers-c212/fusion-marker-proteins-c213/glutathione-s-transferase-gst-antibody-mouse-anti-glutathione-s-transferase-gst-p1091">Glutathione S-transferase (GST) antibody ; Mouse Anti-Glutathione S-transferase (GST)</a></p> <p><p>GST (Glutathione S-Transferase) is a 26kDa protein encoded by the parasitic helminth Schistosoma japonicum and widely used in the pGEX family of GST plasmid expression vectors as a fusion protein with foreign proteins</p></p> http://www.immuquest.com/tags-cell-markers-c212/fusion-marker-proteins-c213/glutathione-s-transferase-gst-antibody-mouse-anti-glutathione-s-transferase-gst-p1091 http://www.immuquest.com/tags-cell-markers-c212/fusion-marker-proteins-c213/glutathione-s-transferase-gst-antibody-mouse-anti-glutathione-s-transferase-gst-p1091 Wed, 25 Jan 2012 13:33:41 +0000 <a href="http://www.immuquest.com/cancer-c52/cancer-metabolism-c197/ppm1-pp2a-methyltransferase-p1090"><img src="http://www.immuquest.com/images/products/thumbnails/1319638717-15908200.jpg" alt="PPM1 (PP2A Methyltransferase)" /></a> <p><a href="http://www.immuquest.com/cancer-c52/cancer-metabolism-c197/ppm1-pp2a-methyltransferase-p1090">PPM1 (PP2A Methyltransferase)</a></p> <p><p>Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues</p></p> http://www.immuquest.com/cancer-c52/cancer-metabolism-c197/ppm1-pp2a-methyltransferase-p1090 http://www.immuquest.com/cancer-c52/cancer-metabolism-c197/ppm1-pp2a-methyltransferase-p1090 Wed, 25 Jan 2012 13:33:41 +0000 <a href="http://www.immuquest.com/signal-transduction-c37/protein-phosphorylation-c210/pp2a-c-terminal-p1089"><img src="http://www.immuquest.com/images/products/thumbnails/1319634046-01298800.jpg" alt="PP2A C-terminal" /></a> <p><a href="http://www.immuquest.com/signal-transduction-c37/protein-phosphorylation-c210/pp2a-c-terminal-p1089">PP2A C-terminal</a></p> <p><p>Functions in cell cycle control and growth factor signaling. PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. It can also dephosphorylate SV40 large T antigen and p53</p></p> http://www.immuquest.com/signal-transduction-c37/protein-phosphorylation-c210/pp2a-c-terminal-p1089 http://www.immuquest.com/signal-transduction-c37/protein-phosphorylation-c210/pp2a-c-terminal-p1089 Wed, 25 Jan 2012 13:33:41 +0000 <a href="http://www.immuquest.com/epigenetics-c31/chromatin-c105/hdac2-antibody-mouse-anti-hdac2-p1088"><img src="http://www.immuquest.com/images/products/thumbnails/1319632283-24531000.jpg" alt="HDAC2 Antibody ; Mouse Anti-HDAC2" /></a> <p><a href="http://www.immuquest.com/epigenetics-c31/chromatin-c105/hdac2-antibody-mouse-anti-hdac2-p1088">HDAC2 Antibody ; Mouse Anti-HDAC2</a></p> <p><p>Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.<br />Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity</p></p> http://www.immuquest.com/epigenetics-c31/chromatin-c105/hdac2-antibody-mouse-anti-hdac2-p1088 http://www.immuquest.com/epigenetics-c31/chromatin-c105/hdac2-antibody-mouse-anti-hdac2-p1088 Wed, 25 Jan 2012 13:33:41 +0000 <a href="http://www.immuquest.com/ageing-c26/eapp-e2f-associated-phosphoprotein-antibody-mouse-anti-eapp-e2f-associated-phosphoprotein-p1087"><img src="http://www.immuquest.com/images/products/thumbnails/1318428377-57161600.jpg" alt="EAPP (E2F- associated phosphoprotein) Antibody ; Mouse Anti-EAPP (E2F- associated phosphoprotein)" /></a> <p><a href="http://www.immuquest.com/ageing-c26/eapp-e2f-associated-phosphoprotein-antibody-mouse-anti-eapp-e2f-associated-phosphoprotein-p1087">EAPP (E2F- associated phosphoprotein) Antibody ; Mouse Anti-EAPP (E2F- associated phosphoprotein)</a></p> <p><p>Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5&#039;-TTTC[CG]CGC-3&#039; found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis</p></p> http://www.immuquest.com/ageing-c26/eapp-e2f-associated-phosphoprotein-antibody-mouse-anti-eapp-e2f-associated-phosphoprotein-p1087 http://www.immuquest.com/ageing-c26/eapp-e2f-associated-phosphoprotein-antibody-mouse-anti-eapp-e2f-associated-phosphoprotein-p1087 Wed, 25 Jan 2012 13:33:41 +0000 <a href="http://www.immuquest.com/signal-transduction-c37/protein-phosphorylation-c210/pp2a-bpr55-alpha-antibody-mouse-anti-pp2a-bpr55-alpha-p1086"><img src="http://www.immuquest.com/images/products/thumbnails/1318426977-26770900.jpg" alt="PP2A B/PR55 alpha Antibody ; Mouse Anti-PP2A B/PR55 alpha" /></a> <p><a href="http://www.immuquest.com/signal-transduction-c37/protein-phosphorylation-c210/pp2a-bpr55-alpha-antibody-mouse-anti-pp2a-bpr55-alpha-p1086">PP2A B/PR55 alpha Antibody ; Mouse Anti-PP2A B/PR55 alpha</a></p> <p><p>PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen</p></p> http://www.immuquest.com/signal-transduction-c37/protein-phosphorylation-c210/pp2a-bpr55-alpha-antibody-mouse-anti-pp2a-bpr55-alpha-p1086 http://www.immuquest.com/signal-transduction-c37/protein-phosphorylation-c210/pp2a-bpr55-alpha-antibody-mouse-anti-pp2a-bpr55-alpha-p1086 Wed, 25 Jan 2012 13:33:41 +0000 <a href="http://www.immuquest.com/ageing-c26/pp2a-bb56-delta-antibody-mouse-anti-pp2a-bb56-delta-p1085"><img src="http://www.immuquest.com/images/products/thumbnails/1318329473-57042100.jpg" alt="PP2A B´/B56 delta Antibody ; Mouse Anti-PP2A B´/B56 delta" /></a> <p><a href="http://www.immuquest.com/ageing-c26/pp2a-bb56-delta-antibody-mouse-anti-pp2a-bb56-delta-p1085">PP2A B´/B56 delta Antibody ; Mouse Anti-PP2A B´/B56 delta</a></p> <p><p>PP2A is a heterotrimeric phosphatase, ccomposed of A, B and C subunits. The structural A and catalytic C subunits form the constitutive core of the enzyme, which associates with one of a large number of regulatory B subunits. Three families of B subunits have been identified thus far. The prototypical B (or PR55) family of subunits is encoded by three genes, Balpha, Bbeta and Bgamma . The B&#039; (or B56) family consists of at least seven splice variantsderived from five genes. RNA&#039;s for the two members of the B&#039;&#039; family, PR72 and PR130, arise by alternative splicing or use of alternate transcription start sites from the same gene. Primary structures as well as functions of B and B&#039; subunits are conserved from yeast to mammals</p></p> http://www.immuquest.com/ageing-c26/pp2a-bb56-delta-antibody-mouse-anti-pp2a-bb56-delta-p1085 http://www.immuquest.com/ageing-c26/pp2a-bb56-delta-antibody-mouse-anti-pp2a-bb56-delta-p1085 Wed, 25 Jan 2012 13:33:41 +0000 <a href="http://www.immuquest.com/nuclear-signalling-c35/chromatin-c124/histone-h4-me1k20-antibody-mouse-anti-histone-h4-me1k20-p1084"><img src="http://www.immuquest.com/images/products/thumbnails/1317822843-13874000.jpg" alt="Histone H4 Me1K20 Antibody ; Mouse Anti-Histone H4 Me1K20" /></a> <p><a href="http://www.immuquest.com/nuclear-signalling-c35/chromatin-c124/histone-h4-me1k20-antibody-mouse-anti-histone-h4-me1k20-p1084">Histone H4 Me1K20 Antibody ; Mouse Anti-Histone H4 Me1K20</a></p> <p><p>Histone proteins H3, H4, H2A, and H2B function as building blocks to package eukaryotic DNA into repeating nucleosome units that are folded in higher order chromatin fibers. The nucleosome is composed of an octamer containing a H3/H4 tetramer and two H2A/H2B dimers, surrounded by approximately 146 base pairs of DNA. A diverse and elaborate array of post-translational modifications including acetylation, phosphorylation, methylation, ubiquitination, and ADP-ribosylation occurs on the N-terminal tail domains of histones.</p> <p>Methylation of position-specific lysine residues in histone N termini is a central modification for regulating epigenetic transitions in chromatin. Each methylatable lysine residue can exist in a mono, di, or tri methylated state. Arginine resdiues can also by mono or di methylated</p></p> http://www.immuquest.com/nuclear-signalling-c35/chromatin-c124/histone-h4-me1k20-antibody-mouse-anti-histone-h4-me1k20-p1084 http://www.immuquest.com/nuclear-signalling-c35/chromatin-c124/histone-h4-me1k20-antibody-mouse-anti-histone-h4-me1k20-p1084 Wed, 25 Jan 2012 13:33:41 +0000 <a href="http://www.immuquest.com/ageing-c26/apolipoprotein-e4-antibody-mouse-anti-apolipoprotein-e4-p1083"><img src="http://www.immuquest.com/images/products/thumbnails/1318326466-17775300.jpg" alt="Apolipoprotein E4 Antibody ; Mouse Anti-Apolipoprotein E4" /></a> <p><a href="http://www.immuquest.com/ageing-c26/apolipoprotein-e4-antibody-mouse-anti-apolipoprotein-e4-p1083">Apolipoprotein E4 Antibody ; Mouse Anti-Apolipoprotein E4</a></p> <p><p>Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents.<br />ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Individuals heterozygous for the ApoE4 allele are at higher risk of late-onset Alzheimer&#039;s disease. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased levels of plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants</p></p> http://www.immuquest.com/ageing-c26/apolipoprotein-e4-antibody-mouse-anti-apolipoprotein-e4-p1083 http://www.immuquest.com/ageing-c26/apolipoprotein-e4-antibody-mouse-anti-apolipoprotein-e4-p1083