Alternative Description: APPL1
Catalogue Number: IQ350
Description: Rabbit Anti-APPL1
Also known as: APPL; DIP13alpha;
Quantity: 50ul
Price: £219.00Price excludes VAT and Delivery.
Clone: N/A;
Host/Isotype: Rabbit;
Immunogen: Purified APPL fusion
Specificity: Human and Mouse APPL1
Purification: Unpurified;
Format: Unpurified antiserum containing 0.1% sodium azide;
Applications: IF; IHC (paraffin sections); WB;
View Applications KeyDilutions: Optimal antibody dilution should be determined by titration, however as a guideline try 1:500
Relevance: The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus
References: (click to view full details)
Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2- Yasuhiro Mitsuuchi et al ( Oncogene,1999)
Research areas: AKT2 interaction; protein binding;
