Alternative Description: Component of gems 2
Catalogue Number: IQ203
Also known as: Gemin2; SIP-1; SIP1 delta; SMN interacting protein 1; SMN interacting protein 1 delta; Survival interacting protein 1;
Quantity: 0.1ml
Price: £365.00Price excludes VAT and Delivery.
Clone: 2E17;
Host/Isotype: Mouse IgG1;
Immunogen: His-Gemin2 (starting at 2nd methionine)
Myeloma/fusion partners: SP2/0;
Specificity: Human gemin2. Detects a band of approximately 34 kDa. Cross reacts with xenopus
Purification: Protein A;
Format: Purified antibody (from supernatant) containing PBS + 0.1% sodium azide;
Applications: E; IF; IP; WB;
View Applications KeyDilutions: Optimal antibody dilution should be determined by titration
Relevance: Involved in biogenesis of spliceosomal snRNPs, forms complex with Survival of Motor Neurons (SMN) protein, interacts tightly with spliceosomal proteins and spliceosomal snRNAs U1 and U5.
References: (click to view full details)
The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins.- Liu Q ( Cell,Sep 1997)
Research areas: Neuroscience; signal transduction;
Storage: Store at +4°C for one month, or in small aliquots at -20°C for longer
Health and safety: Products that contain sodium azide (a poisonous and hazardous substance) should be handled only by trained personnel
Protocols: Immunofluorescence protocol - Formaldehyde fixation; Immunofluorescence protocol - Methanol/acetone fixation; Western Blotting Protocol;
