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Ageing Chromatin

Ageing (a probabilistic decline in a cells ability to repair itself) is a complex process. It is very likely that the aging process is driven by the interplay of different cellular mechanisms, in feedback loops both, exo and endogenous, resulting in damage to a cells to ability to self-repair.

Whilst that complexity and the involvement of DNA damage and epigenetic modifications are no doubt linked it is also the case that chromatin defects ( the cellular structure packaging the combination of DNA and proteins ) plays a key role in ageing.

A key research question is how these processes are linked. Is it that DNA damage leads to chromatin defects? Alternatively, that changes in chromatic structures impacts DNA replication. Most recently it is hypothesized that DNA damage, epigenetic processes and chromatin aberration are more of network of interlinked processes and that a straight linear explanation may be too simplistic.

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Indirect Elisa showing activity of Anti-Acetylated Lysine, clone 7F8
Primary Description:

Mouse Anti-Acetyl Lysine [7F8]

Product Reference Code: IQ354
Species Reactivity:

Chicken, Bovine

Applications:

ELISA, WB

£183.00

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Indirect Elisa showing activity of Anti-Acetylated Lysine, clone 7F8
Primary Description:

Mouse Anti-acetyl Lysine [7F8]

Product Reference Code: IQ355
Species Reactivity:

Chicken, Bovine

Applications:

ELISA, WB

£226.00

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Mouse cortical glia stained with anti-APPL1 Antibody (red) and Hoechst (blue)
Primary Description:

Rabbit Anti-APPL1

Product Reference Code: IQ350
Species Reactivity:

Mouse, Rat, Human

Applications:

IP, WB, ICC/IF, IHC-P

£226.00

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immunofluorescence image showing COS cells stained with BRIT1 Antibody [AB11] expressing GFP microcephalin
Primary Description:

Mouse Anti-BRIT1 [AB11]

Product Reference Code: IQ539
Species Reactivity:

Human

Applications:

WB, ICC/IF, ELISA, IP

£226.00

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Primary Description:

Mouse Anti-HDAC1 [10E2]

Product Reference Code: IQ555
Species Reactivity:

Mouse, Rat, Human

Applications:

Flow Cyt, WB, ICC/IF, IP, ChIP, IHC-P

£226.00

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Primary Description:

Mouse Anti-HDAC1 [10E2]: Fluorescein

Product Reference Code: IQ555FITC
Species Reactivity:

Mouse, Rat, Human

Applications:

Flow Cyt, ICC/IF

£245.00

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Primary Description:

Mouse Anti-HDAC1 [10E2]: Horseradish Peroxidase (HRP)

Product Reference Code: IQ555HRP
Species Reactivity:

Mouse, Rat, Human

Applications:

ChIP, IHC-P, IP, WB

£245.00

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Primary Description:

Mouse Anti-HDAC2 [3F3]

Product Reference Code: IQ544
Species Reactivity:

Mouse, Rat, Human. Predicted to work with Chicken, Cow

Applications:

Flow Cyt, IHC-P, WB, IP, ChIP, ICC/IF

£226.00

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Primary Description:

Mouse Anti-HDAC3 [3G6]

Product Reference Code: IQ553
Species Reactivity:

Human, Mouse 

Applications:

WB , IP , ICC/IF

£226.00

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Primary Description:

Mouse Anti-Histone H3  (tri methyl K9, di methyl K9) [6F12-H4]

Product Reference Code: IQ549
Species Reactivity:

Reacts with Human and cow. predicted to detect many other species due to sequence identity such as Mouse, Rat, Rabbit, Hamster, Pig, Saccharomyces cerevisiae, Fruit fly (Drosophila melanogaster), Non Human Primates

Applications:

Dot blot, WB against endogenous protein, ELISA, ChIP

£226.00

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Primary Description:

Mouse Anti-Histone H4 (tri methyl K20) [6F8-D9]

Product Reference Code: IQ558
Species Reactivity:

Human, Caenorhabditis elegans. Predicted to work with: Xenopus laevis, Arabidopsis thaliana, Fruit fly (Drosophila melanogaster), all Mammals

Applications:

Dot blot, WB against endogenous protein, ELISA, ChIP

£226.00

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Immunoblot analysis of semi-purified HIV-1 virions using clone IN-2 AT 1:2000
Primary Description:

Mouse Anti-HIV1 integrase [IN2]

Product Reference Code: IQ369
Applications:

WB, ICC/IF, IP

£226.00

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-hnRNP U antibody [3G6] staining hnRNPU in human cerebellum
Primary Description:

Mouse Anti-hnRNP U [3G6]

Product Reference Code: IQ210
Species Reactivity:

Mouse, Human, Monkey. Does not react with Chicken, Lizard

Applications:

ELISA, WB, IP, ICC/IF, IHC-P, Flow Cyt, ChIP

£226.00

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Immunostaining reaction of lamin A antibody with human epidermis
Primary Description:

Mouse Anti-Lamin A [133A2]

Product Reference Code: IQ248
Species Reactivity:

Mouse, Rat, Cow, Dog, Human, Monkey

Applications:

Flow Cyt, IHC-Fr, WB, IHC-P, ICC/IF, IP

£183.00

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Lamin expression in basal cell skin carcinomas. Frozen sections stained with Lamin A antibody [JOL4]
Primary Description:

Mouse Anti-Lamin A [JOL4]

Product Reference Code: IQ330
Species Reactivity:

Human, Mouse

Applications:

IF, IHC(Fr), IP, WB

£183.00

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Immunostaining reaction of lamin B2 antibody [LN43] with human epidermis
Primary Description:

Mouse Anti-Lamin B2 [LN43] - Nuclear Envelope Marker

Product Reference Code: IQ250
Species Reactivity:

 Mouse, Hamster, Human, Xenopus laevis, Zebrafish

Applications:

ICC/IF, Flow Cyt, IHC-Fr, WB, IP

£183.00

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