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Ageing DNA Damage Repair

DNA damage has been identified as a key process in ageing in human’s (and other vertebrates) .DNA damage repair is a process in which a cell both indentifies and seeks to correct damage to its genome. DNA damage is impacted by both internal and external events and processes.

Internally, normal metabolic processes can trigger DNA damage. This will include cellular stressors (reactive oxygen species) produced from metabolic events, mutation occurring spontaneously in the organism and cellular replication errors.

Externally, stressors can include, UV light, ionising radiation, toxins, and excessive thermal exposure to the organism in part of whole.

Research in this area aims to indentify the nodes of attack that might trigger cellular processes (senescence and apoptosis) leading to ageing and seek methods of reducing the impact of those internal and external stressors and enabling a more effective cellular repair response profile. The challenge is in identifying which nodes (DNA damage is just one process interlinked with many , which include chromatic aberration and epigenetic events ) are implicated in ageing and how best to intervene.

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Indirect Elisa showing activity of Anti-Acetylated Lysine, clone 7F8
Primary Description:

Mouse Anti-Acetyl Lysine [7F8]

Product Reference Code: IQ354
Species Reactivity:

Chicken, Bovine

Applications:

ELISA, WB

£183.00

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Indirect Elisa showing activity of Anti-Acetylated Lysine, clone 7F8
Primary Description:

Mouse Anti-acetyl Lysine [7F8]

Product Reference Code: IQ355
Species Reactivity:

Chicken, Bovine

Applications:

ELISA, WB

£226.00

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immunofluorescence image showing COS cells stained with BRIT1 Antibody [AB11] expressing GFP microcephalin
Primary Description:

Mouse Anti-BRIT1 [AB11]

Product Reference Code: IQ539
Species Reactivity:

Human

Applications:

WB, ICC/IF, ELISA, IP

£226.00

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Primary Description:

Mouse Anti-Eme1 [7h2/1]

Product Reference Code: IQ284
Species Reactivity:

Human 

Applications:

WB

£183.00

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Western blot - Lamin A + C antibody [JoL5] - Nuclear Envelope Marker
Primary Description:

Mouse Anti-Lamin A + C antibody [JoL5] - Nuclear Envelope Marker

Product Reference Code: IQ188
Species Reactivity:

Mouse, Human

Applications:

ICC/IF, WB

£226.00

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Western blot - Lamin A + C antibody [JoL5] - Nuclear Envelope Marker
Primary Description:

Mouse Anti-Lamin A + C antibody [JoL5] - Nuclear Envelope Marker

Product Reference Code: IQ252
Species Reactivity:

Mouse, Human

Applications:

ICC/IF, WB

£183.00

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Immunostaining reaction of lamin A antibody with human epidermis
Primary Description:

Mouse Anti-Lamin A [133A2]

Product Reference Code: IQ248
Species Reactivity:

Mouse, Rat, Cow, Dog, Human, Monkey

Applications:

Flow Cyt, IHC-Fr, WB, IHC-P, ICC/IF, IP

£183.00

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Lamin expression in basal cell skin carcinomas. Frozen sections stained with Lamin A antibody [JOL4]
Primary Description:

Mouse Anti-Lamin A [JOL4]

Product Reference Code: IQ330
Species Reactivity:

Human, Mouse

Applications:

IF, IHC(Fr), IP, WB

£183.00

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Immunohistochemistry of Anti-Lamin A+C on formalin fixed paraffin embedded skin tissue
Primary Description:

Mouse Anti-Lamin A+C [JOL2]

Product Reference Code: IQ332
Species Reactivity:

Human, African Green Monkey

Applications:

ICC/IF, IHC-Fr, IHC-P, WB, IP, Flow Cyt

£199.00

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Immunocytochemistry/ Immunofluorescence - Lamin A + C antibody [JoL3] - Nuclear Envelope Marker
Primary Description:

Mouse Anti-Lamin A + C antibody [JoL3] - Nuclear Envelope Marker

Product Reference Code: IQ251
Species Reactivity:

Mouse, Rat, Human

Applications:

WB, ICC/IF

£183.00

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Western blot - Mus81 antibody [mta30 2g10/3]
Primary Description:

Mouse Anti-Mus81 [MTA30 2G10/3]

Product Reference Code: IQ285
Species Reactivity:

Human 

Applications:

WB, IP, ICC/IF, Flow Cyt

£183.00

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Primary Description:

Rat Anti-ORC3L [1D6]

Product Reference Code: IQ308
Species Reactivity:

Human 

Applications:

IP, WB

£183.00

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Western blot - PARP2 antibody
Primary Description:

Goat Anti-PARP2

Product Reference Code: IQ547
Species Reactivity:

Human 

Applications:

WB, ELISA

£226.00

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Immunofluorescence - RNA polymerase II CTD repeat YSPTSPS antibody [4H8] in HeLa or MCF7 cells
Primary Description:

Mouse Anti-RNA polymerase II CTD repeat YSPTSPS (phospho S5) [4H8] - ChIP Grade

Product Reference Code: IQ287
Species Reactivity:

Mouse, Human, Saccharomyces cerevisiae, Arabidopsis thaliana, Caenorhabditis elegans, Fruit fly (Drosophila melanogaster), Schizosaccharomyces pombe, African Green Monkey

Applications:

Flow Cyt, ICC/IF, ChIP, ChIP/Chip, WB, ELISA, IP

£183.00

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Immunofluorescence - RNA polymerase II CTD repeat YSPTSPS antibody [4H8] in HeLa or MCF7 cells
Primary Description:

Mouse Anti-RNA polymerase II CTD repeat YSPTSPS (phospho S5) antibody [4H8] - ChIP Grade

Product Reference Code: IQ585
Species Reactivity:

Mouse, Human, Saccharomyces cerevisiae, Arabidopsis thaliana, Caenorhabditis elegans, Fruit fly (Drosophila melanogaster), Schizosaccharomyces pombe, African Green Monkey

Applications:

Flow Cyt, ICC/IF, ChIP, ChIP/Chip, WB, ELISA, IP

£226.00

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Immunocytochemistry/ Immunofluorescence - RNA polymerase II CTD repeat YSPTSPS (phospho S5) antibody [8A7] in Human HeLa cells
Primary Description:

Mouse Anti-RNA polymerase II CTD repeat YSPTSPS (phospho S5) [8A7]

Product Reference Code: IQ295
Species Reactivity:

Human, Saccharomyces cerevisiae. Predicted to work with: Mouse, Hamster, Arabidopsis thaliana, Fruit fly (Drosophila melanogaster), Schizosaccharomyces pombeImmunogen

Applications:

Flow Cyt, ICC/IF, ELISA, WB

£183.00

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