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Ageing Telomeres

A telomere, which plays an important role in cell division is a DNA sequence at the end region of a chromosome and protects the chromosome from fraying damage or the fusing with nearby chromosomes .Each time a cell divides , DNA unwraps and its information copied but the telomere is not copied. When the cell division process is complete, the DNA reforms and the telomereis gets shorter each time this process occurs. The Hayflick limit is the number of times the duplication can take place before the telomere becomes too short potentially damaging the cell and reproduction thereof.

This shorting process is associated with ageing and cancers . However telomeres do not shorten in tissues where cells do not continually divide e.g. heart muscle.

Telomeres and telomerase , an enzyme which adds bases to the end of telomeres may be associated with aging and lifespan although animal studies in mice for example ( which have longer telomeres but a shorter lifespan than humans ) indicate that it is not a strict relationship .

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Western blot - Lamin A + C antibody [JoL5] - Nuclear Envelope Marker
Primary Description:

Mouse Anti-Lamin A + C antibody [JoL5] - Nuclear Envelope Marker

Product Reference Code: IQ188
Species Reactivity:

Mouse, Human

Applications:

ICC/IF, WB

£226.00

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Western blot - Lamin A + C antibody [JoL5] - Nuclear Envelope Marker
Primary Description:

Mouse Anti-Lamin A + C antibody [JoL5] - Nuclear Envelope Marker

Product Reference Code: IQ252
Species Reactivity:

Mouse, Human

Applications:

ICC/IF, WB

£183.00

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Immunostaining reaction of lamin A antibody with human epidermis
Primary Description:

Mouse Anti-Lamin A [133A2]

Product Reference Code: IQ248
Species Reactivity:

Mouse, Rat, Cow, Dog, Human, Monkey

Applications:

Flow Cyt, IHC-Fr, WB, IHC-P, ICC/IF, IP

£183.00

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Lamin expression in basal cell skin carcinomas. Frozen sections stained with Lamin A antibody [JOL4]
Primary Description:

Mouse Anti-Lamin A [JOL4]

Product Reference Code: IQ330
Species Reactivity:

Human, Mouse

Applications:

IF, IHC(Fr), IP, WB

£183.00

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Immunohistochemistry of Anti-Lamin A+C on formalin fixed paraffin embedded skin tissue
Primary Description:

Mouse Anti-Lamin A+C [JOL2]

Product Reference Code: IQ332
Species Reactivity:

Human, African Green Monkey

Applications:

ICC/IF, IHC-Fr, IHC-P, WB, IP, Flow Cyt

£199.00

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Immunocytochemistry - Lamin B1 + B2 antibody [X223] - Nuclear Envelope Marker
Primary Description:

Mouse Anti-Lamin B1 + B2 antibody [X223] - Nuclear Envelope Marker

Product Reference Code: IQ176
Species Reactivity:

Mouse, Rat, Cow, Human

Applications:

ICC/IF, WB 

£226.00

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Immunohistochemistry of lamin B1 antibody [119D5-F1] - Nuclear Envelope Marker on human epidermis
Primary Description:

Mouse Anti-Lamin B1 [119D5-F1] - Nuclear Envelope Marker

Product Reference Code: IQ249
Species Reactivity:

Mouse, Rat, Sheep, Rabbit, Cow, Dog, Human, Zebrafish

Applications:

WB, Dot Blot, ELISA, Flow Cyt, ICC/IF, IHC, IP

£183.00

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Immunostaining reaction of lamin B2 antibody [LN43] with human epidermis
Primary Description:

Mouse Anti-Lamin B2 [LN43] - Nuclear Envelope Marker

Product Reference Code: IQ250
Species Reactivity:

 Mouse, Hamster, Human, Xenopus laevis, Zebrafish

Applications:

ICC/IF, Flow Cyt, IHC-Fr, WB, IP

£183.00

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Immunohistochemistry showing Lamin C on formalin fixed paraffin embedded skin tissue at 1:100
Primary Description:

Rabbit Anti-Lamin C

Product Reference Code: IQ177
Species Reactivity:

Human, Mouse, Rat 

Applications:

ICC/IF, IHC-P, IHC-Fr, WB, Flow

£226.00

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Primary Description:

Mouse Anti-TRF1 [3H11]

Product Reference Code: IQ281
Species Reactivity:

Human 

Applications:

ELISA, ICC/IF, WB

£183.00

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