The Nuclear Envelope, Signalling and the Nuclear Membrane – Lamins and Ageing- Good news emerging?

Studies have implicated Lamins in human disease for years. First in cancer, then in muscular dystrophy and cardiomyopathy, then ten years ago, in 2003 in premature ageing. Most recently, last year, Lamins have been implicated in normal ageing and Nuclear Antibodies against Lamins are now considered as universal markers of the ageing process. Lamins ( designated A,B and C ) … Continue reading

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Cellular mechanisms of cardiomyopathy

Abstract The heart exhibits remarkable adaptive responses to a wide array of genetic and extrinsic factors to maintain contractile function. When compensatory responses are not sustainable, cardiac dysfunction occurs, leading to cardiomyopathy. The many forms of cardiomyopathy exhibit a set of overlapping phenotypes reflecting the limited range of compensatory responses that the heart can use. These include cardiac hypertrophy, induction … Continue reading

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Formation of the postmitotic nuclear envelope from extended ER cisternae precedes nuclear pore assembly

Lu et al. 194 (3): 425 Abstract During mitosis, the nuclear envelope merges with the endoplasmic reticulum (ER), and nuclear pore complexes are disassembled. In a current model for reassembly after mitosis, the nuclear envelope forms by a reshaping of ER tubules. For the assembly of pores, two major models have been proposed. In the insertion model, nuclear pore complexes … Continue reading

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