Visualization of dynein-dependent microtubule gliding at the cell cortex: implications for spindle positioning

Gusnowski and Srayko 194 (3): 377 Abstract Dynein motors move along the microtubule (MT) lattice in a processive “walking” manner. In the one-cell Caenorhabditis elegans embryo, dynein is required for spindle-pulling forces during mitosis. Posteriorly directed spindle-pulling forces are higher than anteriorly directed forces, and this imbalance results in posterior spindle displacement during anaphase and an asymmetric division. To address … Continue reading

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Tem1 localization to the spindle pole bodies is essential for mitotic exit and impairs spindle checkpoint function

Mauricio Valerio-Santiago and Fernando Monje-Casas Abstract The mitotic exit network (MEN) is a signaling cascade that triggers inactivation of the mitotic cyclin-dependent kinases and exit from mitosis. The GTPase Tem1 localizes on the spindle pole bodies (SPBs) and initiates MEN signaling. Tem1 activity is inhibited until anaphase by Bfa1-Bub2. These proteins are also part of the spindle position checkpoint (SPOC), a … Continue reading

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