|
|
Aurora B Antibody - Sheep Anti- Aurora B 0.2ml
Aurora B is a mitotic protein kinase that phosphorylates histone H3 (probably on Serine 10) behaves as a chromosomal passenger protein and may regulate several stages of mitosis such as centrosome separation chromosome segregation and cytokinesis It localizes to the inner centromere region from prophase to anaphase
£226.00
FNIP1 folliculin interacting protein 1 Antibody- Rabbit Anti-FNIP1
Birt-Hogg-Dubé syndrome, a hamartoma disorder characterized by benign tumors of the hair follicle, lung cysts, and renal neoplasia, is caused by germ-line mutations in the BHD(FLCN) gene, which encodes a tumor-suppressor protein, folliculin (FLCN), with unknown function. The tumor-suppressor proteins encoded by genes responsible for several other hamartoma syndromes, LKB1, TSC1/2, and PTEN, have been shown to be involved in the mammalian target of rapamycin (mTOR) signaling pathway
£226.00
HDAC3 Antibody ; Mouse Anti-HDAC3
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation
£226.00
Kallikrein 2 (Hk2) Antibody- Mouse Anti-Kallikrein 2 (Hk2)
Kallikreins (KLKs) are a subgroup of trypsin-like serine proteases and are implicated in carcinogenesis Kallikrein 2 is most closely related to Kallikrein 3 (PSA) with 78 identity and with kallikrein 1 at 68 identity Like Kallikrein 3 Kallikrein 2 is found in greatest abundance in the prostate but at much lower levels than Kallikrein 3 In addition Kallikrein 2 seems to be more labile than Kallikrein 1 or Kallikrein 3 and is often found in a cleaved form Kallikrein 2 is inhibited by Protein C Inhibitor (PCI)
£183.00
Mus81 Antibody- Mouse Anti-Mus81
Reduction or loss of a protein called Mus81 can led to the development of lymphomas and other tumours in mice Mus81 is a protein long thought to be involved in repairing DNA that is damaged during normal metabolic processes
£183.00
NQO1 Antibody- Mouse Anti-NAD(P)H:quinone oxidoreductase 1
This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase This FAD-binding protein forms homodimers and reduces quinones to hydroquinones This proteins enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species Mutations in this gene have been associated with tardive dyskinesia (TD) an increased risk of hematotoxicity after exposure to benzene and susceptibility to various forms of cancer Altered expression of this protein has been seen in many tumors and is also associated with Alzheimers disease (AD) Alternate transcriptional splice variants encoding different isoforms have been characterized
£226.00
NQO1 Antibody- Mouse Anti-NAD(P)H:quinone oxidoreductase 1
This gene (NQO1) is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase This FAD-binding protein forms homodimers and reduces quinones to hydroquinones This proteins enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species Mutations in this gene have been associated with tardive dyskinesia (TD) an increased risk of hematotoxicity after exposure to benzene and susceptibility to various forms of cancer Altered expression of this protein has been seen in many tumors and is also associated with Alzheimers disease (AD) Alternate transcriptional splice variants encoding different isoforms have been characterized
£183.00
OVCA1 Antibody- Rabbit Anti-OVCA1
Chromosome 17 is a hotspot for chromosomal aberrations in breast and ovarian cancer. Candidate oncogenes and tumor suppressors located on this chromosome include OVCA1 and OVCA2, p53, BRCA1, HER2/neu and others. OVCA1 and 2 map to a highly conserved region on human chromosome 17p13.3 that is deleted in 80% of ovarian cancers and shows frequent loss of heterozygosity in breast cancers . OVCA1 is induced by BRCA1 and is closely linked to p53, a well-known tumor suppressor gene. The close linkage of OVCA1 and p53 suggests that coordinated loss of the two genes may lead to ovarian, breast and other tumor types
£226.00
OVCA1 Antibody- Rabbit Anti-OVCA1
Chromosome 17 is a hotspot for chromosomal aberrations in breast and ovarian cancer. Candidate oncogenes and tumor suppressors located on this chromosome include OVCA1 and OVCA2, p53, BRCA1, HER2/neu and others. OVCA1 and 2 map to a highly conserved region on human chromosome 17p13.3 that is deleted in 80% of ovarian cancers and shows frequent loss of heterozygosity in breast cancers . OVCA1 is induced by BRCA1 and is closely linked to p53, a well-known tumor suppressor gene. The close linkage of OVCA1 and p53 suggests that coordinated loss of the two genes may lead to ovarian, breast and other tumor types
£183.00
OVCA2 Antibody- Rabbit Anti-OVCA2
Chromosome 17 is a hotspot for chromosomal aberrations in breast and ovarian cancer. Candidate oncogenes and tumor suppressors located on this chromosome include OVCA1 and OVCA2, p53, BRCA1, HER2/neu and others. OVCA1 and 2 map to a highly conserved region on human chromosome 17p13.3 that is deleted in 80% of ovarian cancers and shows frequent loss of heterozygosity in breast cancers . OVCA1 is induced by BRCA1 and is closely linked to p53, a well-known tumor suppressor gene. The close linkage of OVCA1 and p53 suggests that coordinated loss of the two genes may lead to ovarian, breast and other tumor types
£226.00
PDE5A Antibody- Rabbit Anti- Phosphodiesterase 5A
Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolytic inactivation of the common intracellular second messengers cyclic adenosine and guanosine 3 5-monophosphate (cAMP and cGMP) Thus these enzymes play a critical role in the regulation of a wide range of physiological processes modulated by cyclic nucleotide signalling The PDE5 enzyme belongs to a family of cGMP-dependent PDEs that provide the major means of inactivating the key intracellular second messenger cGMP
£226.00
PPM1 (PP2A Methyltransferase)
Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues
£226.00
Progesterone Receptor Antibody- Phospho (Ser162) - Mouse Anti- Progesterone Receptor - Phospho (Ser162)
Progesterone plays a central role in the reproductive events associated with the establishment and maintenance of pregnancy Progesterone receptor a member of the steroid receptor superfamily mediates the physiologic effects of progesterone The PGR gene uses separate promoters and translational start sites to produce 2 isoforms PRA and PRB which are identical except for an additional 165 amino acids present only in the N terminus of PRB Although PRA and PRB share several structural domains they are distinct transcription factors that mediate their own response genes and physiologic effects with little overlap
£183.00
Progesterone Receptor N559 Antibody- Mouse Anti- Progesterone Receptor N559
Progesterone plays a central role in the reproductive events associated with the establishment and maintenance of pregnancy Progesterone receptor a member of the steroid receptor superfamily mediates the physiologic effects of progesterone The PGR gene uses separate promoters and translational start sites to produce 2 isoforms PRA and PRB which are identical except for an additional 165 amino acids present only in the N terminus of PRB Although PRA and PRB share several structural domains they are distinct transcription factors that mediate their own response genes and physiologic effects with little overlap
£183.00
Progesterone Receptor N559 Antibody- Mouse Anti- Progesterone Receptor N559
Progesterone plays a central role in the reproductive events associated with the establishment and maintenance of pregnancy Progesterone receptor a member of the steroid receptor superfamily mediates the physiologic effects of progesterone The PGR gene uses separate promoters and translational start sites to produce 2 isoforms PRA and PRB which are identical except for an additional 165 amino acids present only in the N terminus of PRB Although PRA and PRB share several structural domains they are distinct transcription factors that mediate their own response genes and physiologic effects with little overlap
£226.00
