Hormones and the receptor sites thereof can be implicated in the growth of certain cancers particularly those associated which are sex related e.g. Breast , Prostate, Ovary and Teste’s . Hormones basic role is promotion of growth and cell proliferation and hormones are therefore key instigators of gene expression in certain cancer cells. Manipulating hormone pathways ,when present, can result in cancers ceasing to grow and even cell death.
The presence or absence of hormone receptors is an important standardised test in focusing therapeutic diagnosis and treatment.
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3D1.1 Antibody (Parathyroid hormone like protein) - Mouse Anti PTHLH
The protein encoded by this gene is a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone, PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, in-frame and downstream of the initiator AUG codon, to give rise to nuclear forms of this hormone
£226.00
Adrenocorticotropic hormone (ACTH) N-Terminal Antibody - Mouse Anti-Adrenocorticotropic hormone (ACTH) N-Terminal
ACTH occurs in cells of the anterior pituitary and in neurons in brain. It regulates the corticosteroid production in the adrenal cortex. Beta endorphin and Met enkephalin are endogenous opiates. MSH (melanocyte stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes
£226.00
HCG beta Antibody- Mouse anti-HCG beta
Human chorionic gonadotropin (hCG) is a glycoprotein hormone produced by trophoblastic cells of the placenta beginning 10 to 12 days after conception. Maintenance of the fetus in the first trimester of pregnancy requires the production of hCG, which binds to the corpus luteum of the ovary which is stimulated to produce progesterone which in turn maintains the secretory endometrium. The unique beta chain confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin. hCG acts to maintain the corpus luteum until the developing placenta is able to produce the required levels of oestrogen and progesterone.
£226.00
Parathyroid Hormone Antibody - Mouse Anti-Parathyroid Hormone (PTH)
The protein encoded by this gene is a hormone secreted by parathyroid cells. This hormone elevates blood Ca2+ level by dissolving the salts in bone and preventing their renal excretion. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH)
£226.00
TGF beta Antibody- Mouse Anti-Human TGF beta
TGFB is a multifunctional peptide that controls proliferation differentiation and other functions in many cell types TGFB acts synergistically with TGFA (MIM 190170) in inducing transformation It also acts as a negative autocrine growth factor Dysregulation of TGFB activation and signaling may result in apoptosis Many cells synthesize TGFB and almost all of them have specific receptors for this peptide TGFB1 TGFB2 (MIM 190220) and TGFB3 (MIM 190230) all function through the same receptor signaling systems
£226.00
