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Cancer Proto-oncogenes

Proto oncogenes are normal genes which carry the potential to be cancer forming ones and can be triggered through mutagenic processes, cell growth regulation failure or an abnormal translocation of a chromosome.

Oncogenes activate cells to grow and replicate when in normal circumstances cells would under go apoptosis.

Oncoproteins are then produced from the oncogenic gene expression as result of mutation of a normal gene into an onco gene, one which may have the potential to cause cancer.

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OVCA2 Antibody- Rabbit Anti-OVCA2
Chromosome 17 is a hotspot for chromosomal aberrations in breast and ovarian cancer. Candidate oncogenes and tumor suppressors located on this chromosome include OVCA1 and OVCA2, p53, BRCA1, HER2/neu and others. OVCA1 and 2 map to a highly conserved region on human chromosome 17p13.3 that is deleted in 80% of ovarian cancers and shows frequent loss of heterozygosity in breast cancers . OVCA1 is induced by BRCA1 and is closely linked to p53, a well-known tumor suppressor gene. The close linkage of OVCA1 and p53 suggests that coordinated loss of the two genes may lead to ovarian, breast and other tumor types
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