The Ras family are a type of G proteins which are responsible for cell proliferation, a process which can, abnormally, lead to cancer formation and its metastasis.
The Ras are part of super family which number more than a hundred and are known as Small GTPpases, enzymes which hydrolyse GTP (Guanosine triphosphate) to form GDP. Small GTPpases regulate cell growth, differentiation and lipid vesicle transportation.
The process of metastasis is complex, requiring cell proliferation triggers, cell motility, apoptosis inhibition et al. The Ras oncogene is implicated in 30% of all cancers.
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Ran Antibody- Rabbit Anti-Ran
Ran (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex The Ran protein is also involved in control of DNA synthesis and cell cycle progression Nuclear localization of Ran requires the presence of regulator of chromosome condensation 1 (RCC1) Mutations in Ran disrupt DNA synthesis Because of its many functions it is likely that Ran interacts with several other proteins Ran regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules Ran could be a key signaling molecule regulating microtubule polymerization during mitosis RCC1 generates a high local concentration of Ran-GTP around chromatin which in turn induces the local nucleation of microtubules Ran is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor Polyglutamine repeat expansion in the AR is linked to Kennedys disease (X-linked spinal and bulbar muscular atrophy) Ran coactivation of the AR diminishes with polyglutamine expansion within the AR and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedys disease
£183.00
