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Cancer Ras Family

The Ras family are a type of G proteins which are responsible for cell proliferation, a process which can, abnormally, lead to cancer formation and its metastasis.

The Ras are part of super family which number more than a hundred and are known as Small GTPpases, enzymes which hydrolyse GTP (Guanosine triphosphate) to form GDP. Small GTPpases regulate cell growth, differentiation and lipid vesicle transportation.

The process of metastasis is complex, requiring cell proliferation triggers, cell motility, apoptosis inhibition et al. The Ras oncogene is implicated in 30% of all cancers.

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