|
|
Cytokeratin (keratin) K2 (AE3) Antibody- Mouse Anti-Cytokeratin (keratin) K2 (AE3)
Cytokeratins, a group of at least 29 different proteins, are characteristic of epithelial and trichocytic cells. Cytokeratins 4, 5, 6 and 8 are members of the type II neutral-to-basic subfamily. Cytokeratin peptide 4 (59 kDa) is the secondary type II keratin expressed in non cornified stratified squamous epithelia. Cytokeratin peptide 5 (58 kDa) is the primary type II keratin in stratified epithelia, while cytokeratin type 8 (52 kDa) is a major type II keratin in simple epithelia. Cytokeratin 6 (56 kDa) is a "hyperproliferation" cytokeratin expressed in tissues with natural or pathological high turnover. Cytokeratins 10, 13 and 18 are members of the type I acidic subfamily. Cytokeratin peptide 10 (56 kDa) is the secondary type I keratin expressed in cornified epithelia. Cytokeratin 13 (54 kDa) is the secondary type I keratin expressed in non-cornified stratified squamous epithelia. Cytokeratin 18 (45 kDa) is the primary type I keratin expressed in simple epithelial cells.
£226.00
MCPH1 (BRIT1) Antibody- Mouse Anti-MCPH1 (BRIT1)
This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome
MCPH1 looks like it might be a useful prognostic indicator in breast cancer associated with BRCA1 inactivation
£226.00
Nestin Antibody- Mouse Anti-Nestin
Nestin is a Class VI intermediate filament expressed in the developing central nervous system (CNS) in early embryonic neuroepithelial stem cells This protein has been widely used as a predominant marker for stem / progenitor cells glioma cells and tumor endothelial cells in the mammalian CNS Furthermore it is a superior angiogenic marker to evaluate neovascularity of endothelial cells in tumor This highly specific antibody to human nestin can aid in characterizing progenitor cells differentiating into distinct lineages in enhancing the therapeutic potential of human neural stem/progenitor cells in the treatment of CNS diseases or injury and in identifying neuroepithelial tumor cells
£183.00
Neurocan Antibody- Mouse Anti-Neurocan
Neurocan is the major soluble chondroitin sulfate proteoglycan in the brain It is thought to play a functional role in axonal growth and guidance and in the establishment of specific neural pathways during embryonic brain development Neurocan expression in the brain is developmentally regulated Early on the major form of neurocan consists of a 245kD core protein with approximately two chondroitin sulfate glycosoaminoglycan chains of 22kD each Later neurocan comprises a 180kD core protein Both forms of neurocan contain only chondroitin 4-sulfate glycosoaminoglycan chains By virtue of their high expression at sites of neural damage and trauma chondroitin sulfate proteoglycans including neurocan are thought to inhibit successful nerve regeneration
£183.00
NeurocanAntibody - Mouse Anti-Neurocan
Neurocan is the major soluble chondroitin sulfate proteoglycan in the brain It is thought to play a functional role in axonal growth and guidance and in the establishment of specific neural pathways during embryonic brain development Neurocan expression in the brain is developmentally regulated Early on the major form of neurocan consists of a 245kD core protein with approximately two chondroitin sulfate glycosoaminoglycan chains of 22kD each Later neurocan comprises a 180kD core protein Both forms of neurocan contain only chondroitin 4-sulfate glycosoaminoglycan chains By virtue of their high expression at sites of neural damage and trauma chondroitin sulfate proteoglycans including neurocan are thought to inhibit successful nerve regeneration
£226.00
Trichohyalin granules (THG) AE15 Antibody- Mouse Anti-trichohyalin granules (THG) AE15
Trichohyalin is a hair follicle protein with characteristics similar to those of profilaggrin (135940) involucrin (147360) and loricrin (152445) Trichohyalin is incorporated into the IF (intermediate filament)-like structures in the mature cells of the hair follicles inner root sheath Like profilaggrin involucrin and loricrin trichohyalin becomes highly crosslinked by the enzyme transglutaminase The trichohyalin molecule has a mass of approximately 200 kD and consists predominantly of tandem repeats of an approximately 23-amino acid sequence Fietz et al (1992) used a sheep trichohyalin cDNA probe in tritium-labeled in situ hybridization to demonstrate that the human THL gene is located in the region 1q211-q23 probably 1q213 Profilaggrin involucrin and loricrin map to the same area suggesting that the 4 proteins form a novel superfamily of epithelial structural proteins By analysis of human-rodent somatic cell hybrids and fluorescence in situ hybridization Lee et al (1993) confirmed the mapping of THL to 1q21
£183.00
