A Centromere is an area of DNA found in the middle of a chromosome, where two chromatids come closest to each other. Centromeres are essential to cell division as the point of the mitotic spindle attachment. They come in two types; regional and point types. Regional types contain large amounts of DNA and point types are smaller and contain more compact DNA bundles. Centromeres are crucial in cell division enabling chromosome attachment to polar fibres which help to manipulate and separate the chromosome during mitosis.
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Aurora B Antibody - Sheep Anti- Aurora B 0.2ml
Aurora B is a mitotic protein kinase that phosphorylates histone H3 (probably on Serine 10) behaves as a chromosomal passenger protein and may regulate several stages of mitosis such as centrosome separation chromosome segregation and cytokinesis It localizes to the inner centromere region from prophase to anaphase
£226.00
BUB1 Antibody - Mouse (monoclonal) Anti-BUB1 0.1ml
Bub1 is a kinase involved in spindle checkpoint function The kinase functions in part by phosphorylating a member of the miotic checkpoint complex and activating the spindle checkpoint Mutations in Bub1 have been associated with aneuploidy and several forms of cancer
£226.00
BUB1 Antibody - Mouse Anti-BUB1 50ul
Bub1 is a kinase involved in spindle checkpoint function The kinase functions in part by phosphorylating a member of the miotic checkpoint complex and activating the spindle checkpoint Mutations in Bub1 have been associated with aneuploidy and several forms of cancer
£183.00
CENP-E Antibody - Mouse Anti-CENP-E 0.1ml
CENPE is a 250-300 kDa human centromere-associated kinesin-like motor protein that accumulates in G2 phase In contrast to other centromere proteins CENPE is not detected at centromeres during interphase and first appears at the centromere region of chromosomes during prometaphase CENPE function is required for the transition from metaphase to anaphase CENPE is probably one of the motors responsible for mammalian chromosome movement and/or spindle elongation
£226.00
CENP-E Antibody - Mouse Anti-CENP-E 50ul
CENPE is a 250-300 kDa human centromere-associated kinesin-like motor protein that accumulates in G2 phase In contrast to other centromere proteins CENPE is not detected at centromeres during interphase and first appears at the centromere region of chromosomes during prometaphase CENPE function is required for the transition from metaphase to anaphase CENPE is probably one of the motors responsible for mammalian chromosome movement and/or spindle elongation
£183.00
ORC2 (origin recognition complex 2) Antibody- Rat Anti-ORC2
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins ORC2L is a subunit of the ORC complex ORC2L forms a core complex with ORC3L 4L and 5L It also interacts with CDC45L and MCM10 which are proteins known to be important for the initiation of DNA replication ORC2L specifically associate with the origin of replication of Epstein Barr virus in human cells and is thought to be required for DNA replication from viral origin of replication
£183.00
PP2A C Antibody ; Mouse Anti-PP2A C
PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen
£226.00
PPM1 (PP2A Methyltransferase)
Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues
£226.00
RanGAPAntibody - Rabbit Anti-RanGAP
Ran is a small signaling GTPase that is involved in nucleocytoplasmic
transport. Two additional functions of animal Ran in the formation of spindle
asters and the reassembly of the nuclear envelope in mitotic cells have been
recently reported. In contrast to Ras or Rho, Ran is not associated with
membranes. Instead, the spatial sequestering of its accessory proteins, the Ran
GTPase-activating protein RanGAP and the nucleotide exchange factor RCC1,
appears to define the local concentration of RanGTP vs. RanGDP involved in
signaling. Mammalian RanGAP is bound to the nuclear pore by a mechanism
involving the attachment of small ubiquitin-related modifier protein (SUMO)
to its C terminus and the subsequent binding of the SUMOylated domain to the
nucleoporin Nup358
£183.00
