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A Centromere is an area of DNA found in the middle of a chromosome, where two chromatids come closest to each other. Centromeres are essential to cell division as the point of the mitotic spindle attachment. They come in two types; regional and point types. Regional types contain large amounts of DNA and point types are smaller and contain more compact DNA bundles. Centromeres are crucial in cell division enabling chromosome attachment to polar fibres which help to manipulate and separate the chromosome during mitosis.