A centrosome is a specialised cellular sub unit or organelle that acts as the main microtubule organising structure in the cell. Centrosomes are implicated in the accuracy and efficacy of cellular division and cell cycle progression.
Centrosomes can be altered in cancer cells with both structural and numeric aberrations. With structural aberrations the centrosome variations appear too large due to uncontrolled expression of certain core components and this type of enlargement can often been seen in tumours. Numeric aberrations, excessive or even supernumerary, generated by reduplication or cell division failures is a common event in tumours.>
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Aurora B Antibody - Sheep Anti- Aurora B 0.2ml
Aurora B is a mitotic protein kinase that phosphorylates histone H3 (probably on Serine 10) behaves as a chromosomal passenger protein and may regulate several stages of mitosis such as centrosome separation chromosome segregation and cytokinesis It localizes to the inner centromere region from prophase to anaphase
£226.00
ORC2 (origin recognition complex 2) Antibody- Rat Anti-ORC2
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins ORC2L is a subunit of the ORC complex ORC2L forms a core complex with ORC3L 4L and 5L It also interacts with CDC45L and MCM10 which are proteins known to be important for the initiation of DNA replication ORC2L specifically associate with the origin of replication of Epstein Barr virus in human cells and is thought to be required for DNA replication from viral origin of replication
£183.00
