Chromatin is DNA and proteins combined together that make up the contents of the cell. Chromatin ensures DNA fits into the cell and is implicated in cell division, DNA replication and gene expression.
Whilst that complexity and the involvement of DNA damage and epigenetic modifications are no doubt linked it is also the case that chromatin defects the cellular structure packaging the combination of DNA and proteins plays a key role in ageing.
A key research question is how these processes are linked? Is it that DNA damage leads to chromatin defects? Or that changes in chromatic structures impacts DNA replication? Most recently it is hypothesized that DNA damage, epigenetic processes and chromatin aberration are more of network of interlinked processes and that a more straight linear explanation may be too simplistic.
Primary Description: | Mouse Anti-acetyl Lysine [7F8] |
Product Reference Code: | IQ355 |
Species Reactivity: | Chicken, Bovine |
Applications: | ELISA, WB |
Primary Description: | Rabbit Anti-APPL1 |
Product Reference Code: | IQ350 |
Species Reactivity: | Mouse, Rat, Human |
Applications: | IP, WB, ICC/IF, IHC-P |
Primary Description: | Mouse Anti-BRIT1 [AB11] |
Product Reference Code: | IQ539 |
Species Reactivity: | Human |
Applications: | WB, ICC/IF, ELISA, IP |
Primary Description: | Mouse Anti-HDAC1 [10E2] |
Product Reference Code: | IQ555 |
Species Reactivity: | Mouse, Rat, Human |
Applications: | Flow Cyt, WB, ICC/IF, IP, ChIP, IHC-P |
Primary Description: | Mouse Anti-HDAC2 [3F3] |
Product Reference Code: | IQ544 |
Species Reactivity: | Mouse, Rat, Human. Predicted to work with Chicken, Cow |
Applications: | Flow Cyt, IHC-P, WB, IP, ChIP, ICC/IF |
Primary Description: | Mouse Anti-HDAC3 [3G6] |
Product Reference Code: | IQ553 |
Species Reactivity: | Human, Mouse |
Applications: | WB , IP , ICC/IF |
Primary Description: | Mouse Anti-Histone H4 (mono methyl K20) [5E10-D8] |
Product Reference Code: | IQ551 |
Species Reactivity: | Human. Predicted to work with: Xenopus laevis, Arabidopsis thaliana, Fruit fly (Drosophila melanogaster), all Mammals |
Applications: | Dot blot, WB against endogenous protein, ELISA, ChIP |
Primary Description: | Mouse Anti-Histone H4 (tri methyl K20) [6F8-D9] |
Product Reference Code: | IQ558 |
Species Reactivity: | Human, Caenorhabditis elegans. Predicted to work with: Xenopus laevis, Arabidopsis thaliana, Fruit fly (Drosophila melanogaster), all Mammals |
Applications: | Dot blot, WB against endogenous protein, ELISA, ChIP |
Primary Description: | Mouse Anti-HIV1 integrase [IN2] |
Product Reference Code: | IQ369 |
Applications: | WB, ICC/IF, IP |
Primary Description: | Mouse Anti-hnRNP U [3G6] |
Product Reference Code: | IQ210 |
Species Reactivity: | Mouse, Human, Monkey. Does not react with Chicken, Lizard |
Applications: | ELISA, WB, IP, ICC/IF, IHC-P, Flow Cyt, ChIP |
Primary Description: | Mouse Anti-Lamin A [133A2] |
Product Reference Code: | IQ248 |
Species Reactivity: | Mouse, Rat, Cow, Dog, Human, Monkey |
Applications: | Flow Cyt, IHC-Fr, WB, IHC-P, ICC/IF, IP |
Primary Description: | Mouse Anti-Lamin A [JOL4] |
Product Reference Code: | IQ330 |
Species Reactivity: | Human, Mouse |
Applications: | IF, IHC(Fr), IP, WB |
Primary Description: | Mouse Anti-Lamin B2 [LN43] - Nuclear Envelope Marker |
Product Reference Code: | IQ250 |
Species Reactivity: | Mouse, Hamster, Human, Xenopus laevis, Zebrafish |
Applications: | ICC/IF, Flow Cyt, IHC-Fr, WB, IP |
Primary Description: | Rabbit Anti-Lamin C |
Product Reference Code: | IQ177 |
Species Reactivity: | Human, Mouse, Rat |
Applications: | ICC/IF, IHC-P, IHC-Fr, WB, Flow |
Primary Description: | Rabbit Anti-LAP2 alpha |
Product Reference Code: | IQ175 |
Species Reactivity: | Mouse, Rat, Human |
Applications: | ChIP, IP, ICC/IF, WB |
Primary Description: | Rabbit Anti-Mad1 |
Product Reference Code: | IQ242 |
Species Reactivity: | Saccharomyces cerevisiae |
Applications: | WB, ICC/IF |