My Account My Wishlist

• Home
• Antibody Categories

  Cell Adhesion Marker Antibodies Cell Cycle Antibodies Cell Signalling Antibodies Checkpoint Control Antibodies Chemokine Receptor Antibodies Cytoskeleton Antibodies Disease Related Antibodies DNA Damage Recognition Antibodies Growth Factor Antibodies Hormone & Receptor Antibodies Immunology Antibodies Metabolism Antibodies

  Microbiology Antibodies Neuroscience Antibodies Nuclear Envelope Antibodies Nuclear Pore Complex Antibodies Nuclear Transport Antibodies Phototransduction Antibodies Rna Binding Protein Antibodies Tag Antibodies T Cell Receptor Antibodies Viral Transcription Antibodies

• Research Areas

  Ageing » Stress Proteins Apoptosis Chromatin DNA Damage Repair Lamins Neurodegeneration Telomeres Tumor Suppressors Cancer » Angiogenic Factors Apoptosis Co-activators/co-repressors DNA Synthesis Growth Factors Hormones Receptors HIV Lamins Oncoproteins Proto-oncogenes Ras Family Telomeres Tumor Suppressors Cancer Metabolism Cytokines Cell Adhesion Cyclins Cell Biology » Post-transitional modifications Metabolic Enzymes Metabolism Apoptosis Cell Movement Cell Proliferation Centromere Centrosomes Chromatin Cytoskeleton Growth Factors Intermediate Filaments Kallikreins Lamins mRNA processing Nuclear Envelope Nuclear Import / Export Oncoproteins P bodies/GW bodies Receptor Proteins RNA Processing Steroid Hormone Receptors Cyclins Cell Division » Centromere Centrosomes Checkpoint Proteins DNA Synthesis Lamins Oncoproteins Signal Transduction Telomeres Tumor Suppressors Cell Architecture » Actin Cytoskeleton Cell Adhesion Molecules Centromere Centrosomes Cytoskeleton Extra Cellular Matrix Proteins Intermediate Filaments Lamins Nuclear Envelope Microtubule Cytoskeleton Development » Acetylation Apoptosis Chromatin Co-activators/co-repressors Cytokeratins Growth Factors HLH / Leucine Zipper Hormones Receptors Lamins Oncoproteins Germ Cell Markers Epigenetics » Acetylation Chromatin Lamins Nuclear Envelope Cyclins Hypoxia Telomeres Histones Human Disease » Inherited Degenerative Disorders Cognitive/Mental Disorders Infectious Diseases Immune Deficiency Immunology » Complement Cytokines B-cell Markers HIV Influenza T-cell Markers Immunoglobulin Macrophage / inflammation Inherited Diseases » Cytokeratins Intermediate Filaments Lamins Neurodegeneration Nuclear Envelope Oncoproteins Tumor Suppressors Microbiology » Calcium ion binding HIV Influenza Metal Ion Binding Toxin Nematoda Virus Host Virus Interaction Protozoa Bacteria Nuclear Signalling » Apoptosis Chromatin Lamins Nuclear Envelope Nuclear Import / Export Nuclear Pores Nucleoplasm RNA Processing Spliceosomes Telomeres Neuroscience » Metabolism Visual System Extracellular Matrix Neurodegeneration Neuronal Markers Neuron Parkinsons Disease Glutamate Receptors Ageing Signal Transduction » Stress Pathways Cadherins Actin Binding Proteins Cell Adhesion Intermediate Filaments Extracellular Matrix Acetylation Cell Division Co-activators/co-repressors Growth Factors HLH / Leucine Zipper Hormones Receptors Lamins Lipid binding Protein Phosphorylation Proto-oncogenes Ras Family Receptor Proteins Steroid Hormone Receptor Activity Transmembrane Telomeres Tumor Suppressors Sub Cellular markers » Chromatin Cytokeratins Golgi Apparatus Intermediate Filaments Lamins Lysosomes Nuclear Envelope Plasma Membranes Stem Cells » CD Antigens Transcription » Acetylation Chromatin Co-activators / co-repressors HLH / Leucine Zipper mRNA processing Oncoproteins RNA Processing RNA Synthesis Splicing Immunohistochemistry

• New Antibodies
• Services

  Antibody Licensing Research Customer Service Protocols Custom Antibody Services Our Antibodies Product Assurance Guarantee

• About
• Support
• Distributors
• OEM Customers
• Contact

Chromatin is DNA and proteins combined together that make up the contents of the cell. Chromatin ensures DNA fits into the cell and is implicated in cell division, DNA replication and gene expression.

Whilst that complexity and the involvement of DNA damage and epigenetic modifications are no doubt linked it is also the case that chromatin defects the cellular structure packaging the combination of DNA and proteins plays a key role in ageing.

A key research question is how these processes are linked? Is it that DNA damage leads to chromatin defects? Or that changes in chromatic structures impacts DNA replication? Most recently it is hypothesized that DNA damage, epigenetic processes and chromatin aberration are more of network of interlinked processes and that a more straight linear explanation may be too simplistic.