mRNA, messenger ribonucleic acid, is a molecule of RNA that encodes a chemical blueprint for a protein. mRNA is transcribed from a DNA template, and carries a code to the cell ribosome’s where protein synthesis takes place.
The molecule itself is constructed of a protective cap, a region of codons essential for carrying the key information to be passed on, two untranslated codon regions which ensure molecule stability inter alia, and a poly tail area that prevents premature degrading.
The genetic information, carried in codons of three base pairs each, codes for specific proteins. Once the transport cycle has completed the mRNA degrades.
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ALY Antibody - Mouse Anti-ALY 50ul
The protein encoded by this gene is a heat stable nuclear protein and functions as a molecular chaperone It is thought to regulate dimerization DNA binding and transcriptional activity of basic region-leucine zipper (bZIP) proteins
£183.00
Gemin1/SMN Antibody- Mouse Anti-SMN
This gene is part of a 500 kb inverted duplication on chromosome 5q13 This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region The telomeric and centromeric copies of this gene are nearly identical and encode the same protein However mutations in this gene the telomeric copy are associated with spinal muscular atrophy mutations in the centromeric copy do not lead to disease The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy The critical sequence difference between the two genes is a single nucleotide in exon 7 which is thought to be an exon splice enhancer It is thought that gene conversion events may involve the two genes leading to varying copy numbers of each gene The protein encoded by this gene localizes to both the cytoplasm and the nucleus Within the nucleus the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs) This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN 4 and also interacts with several proteins known to be involved in the biogenesis of snRNPs such as hnRNP U protein and the small nucleolar RNA binding protein Two transcript variants are produced by this gene
£226.00
hnRNP-L Antibody- Mouse Anti-hnRNP-L
Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation packaging processing and function of mRNA Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex HNRP proteins have also been identified outside of the nucleoplasm Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm it is possible that they also have cytoplasmic functionsStrucutrally HNRPL contains 2 segments of approximately 80 amino acids each which are weakly related to each other and to the ribonucleoprotein consensus sequence-type RNA-binding domains of other hnRNP and snRNP proteins
£226.00
