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FMR1 (Drosophila) Antibody- Mouse (monoclonal) Anti-FMR1
Fragile X syndrome is the most common inherited form of mental retardation It is caused by loss of FMR1 gene activity due to either lack of expression or expression of a mutant form of the protein In mammals FMR1 is a member of a small protein family that consists of FMR1 FXR1 and FXR2 All three members bind RNA and contain sequence motifs that are commonly found in RNA-binding proteins including two KH domains and an RGG boxThe Drosophila genome contains a single gene homologous to the FXR family dFMR1 is subjected to transcriptional and posttranscriptional regulation during development and it homomerizes like its human counterpart dFMR1 profile of expression recapitulates that of the human FXR protein family it is highly enriched in muscles in central nervous system and in gonads In the larval brain anti-dFMR1 also recognizes mushroom bodies a centre that mediates learning and memory These features make the fly an ideal system to analyse the role of the FXR family and to identify genes in the FMRP pathway
£226.00
FMR1 (Drosophila) Antibody- Mouse Anti-FMR1 (Drosophila)
Fragile X syndrome is the most common inherited form of mental retardation It is caused by loss of FMR1 gene activity due to either lack of expression or expression of a mutant form of the protein In mammals FMR1 is a member of a small protein family that consists of FMR1 FXR1 and FXR2 All three members bind RNA and contain sequence motifs that are commonly found in RNA-binding proteins including two KH domains and an RGG boxThe Drosophila genome contains a single gene homologous to the FXR family dFMR1 is subjected to transcriptional and posttranscriptional regulation during development and it homomerizes like its human counterpart dFMR1 profile of expression recapitulates that of the human FXR protein family it is highly enriched in muscles in central nervous system and in gonads In the larval brain anti-dFMR1 also recognizes mushroom bodies a centre that mediates learning and memory These features make the fly an ideal system to analyse the role of the FXR family and to identify genes in the FMRP pathway
£226.00
hnRNP-A1 Antibody- Mouse Anti-hnRNP-A1
This protein belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs) The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA) These proteins are associated with pre mRNAs in the nucleus and appear to influence pre mRNA processing and other aspects of mRNA metabolism and transport While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm The hnRNP proteins have distinct nucleic acid binding properties hnRNP A1 has two repeats of quasi RRM domains that bind to RNAs It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm This protein along with other hnRNP proteins is exported from the nucleus probably bound to mRNA and is immediately re imported Its M9 domain acts as both a nuclear localization and nuclear export signal The encoded protein is involved in the packaging of pre mRNA into hnRNP particles transport of poly A mRNA from the nucleus to the cytoplasm and may modulate splice site selection It is also thought to have a primary role in the formation of specific myometrial protein species in parturition Multiple alternatively spliced transcript variants have been found for the hnRNP A1 gene but only two transcripts are fully described These variant have multiple alternative transcription initiation sites and multiple polyA sites
£226.00
hnRNP-A1 Antibody- Mouse Anti-hnRNP-A1
This protein belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs) The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA) These proteins are associated with pre mRNAs in the nucleus and appear to influence pre mRNA processing and other aspects of mRNA metabolism and transport While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm The hnRNP proteins have distinct nucleic acid binding properties hnRNP A1 has two repeats of quasi RRM domains that bind to RNAs It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm This protein along with other hnRNP proteins is exported from the nucleus probably bound to mRNA and is immediately re imported Its M9 domain acts as both a nuclear localization and nuclear export signal The encoded protein is involved in the packaging of pre mRNA into hnRNP particles transport of poly A mRNA from the nucleus to the cytoplasm and may modulate splice site selection It is also thought to have a primary role in the formation of specific myometrial protein species in parturition Multiple alternatively spliced transcript variants have been found for the hnRNP A1 gene but only two transcripts are fully described These variant have multiple alternative transcription initiation sites and multiple polyA sites
£226.00
hnRNP-A1 Antibody- Mouse Anti-hnRNP-A1
This protein belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs) The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA) These proteins are associated with pre mRNAs in the nucleus and appear to influence pre mRNA processing and other aspects of mRNA metabolism and transport While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm The hnRNP proteins have distinct nucleic acid binding properties hnRNP A1 has two repeats of quasi RRM domains that bind to RNAs It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm This protein along with other hnRNP proteins is exported from the nucleus probably bound to mRNA and is immediately re imported Its M9 domain acts as both a nuclear localization and nuclear export signal The encoded protein is involved in the packaging of pre mRNA into hnRNP particles transport of poly A mRNA from the nucleus to the cytoplasm and may modulate splice site selection It is also thought to have a primary role in the formation of specific myometrial protein species in parturition Multiple alternatively spliced transcript variants have been found for the hnRNP A1 gene but only two transcripts are fully described These variant have multiple alternative transcription initiation sites and multiple polyA sites
£183.00
hnRNP-A1 Antibody- Mouse Anti-hnRNP-A1
This protein belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs) The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA) These proteins are associated with pre mRNAs in the nucleus and appear to influence pre mRNA processing and other aspects of mRNA metabolism and transport While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm The hnRNP proteins have distinct nucleic acid binding properties hnRNP A1 has two repeats of quasi RRM domains that bind to RNAs It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm This protein along with other hnRNP proteins is exported from the nucleus probably bound to mRNA and is immediately re imported Its M9 domain acts as both a nuclear localization and nuclear export signal The encoded protein is involved in the packaging of pre mRNA into hnRNP particles transport of poly A mRNA from the nucleus to the cytoplasm and may modulate splice site selection It is also thought to have a primary role in the formation of specific myometrial protein species in parturition Multiple alternatively spliced transcript variants have been found for the hnRNP A1 gene but only two transcripts are fully described These variant have multiple alternative transcription initiation sites and multiple polyA sites
£183.00
hnRNP-K/J Antibody- Mouse (monoclonal) Anti-hnRNP-K/J
Particulate complex of heterogeneous nuclear RNA (hnRNA) is a heterogeneous mixture of RNA molecules of high Mr with a rapid turnover rate that occurs in cell nuclei during protein synthesis with proteins which are cell specific and heterogeneous The protein component may play a role in the processing of the hnRNA to mRNA
£226.00
hnRNP-K/J Antibody- Mouse Anti-hnRNP-K/J
Particulate complex of heterogeneous nuclear RNA (hnRNA) is a heterogeneous mixture of RNA molecules of high Mr with a rapid turnover rate that occurs in cell nuclei during protein synthesis with proteins which are cell specific and heterogeneous The protein component may play a role in the processing of the hnRNA to mRNA
£183.00
Magoh Antibody- Mouse Anti-Magoh
Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development This gene encodes the mammalian mago nashi homolog In mammals mRNA expression is not limited to the germ plasm but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts
£226.00
Magoh Antibody- Mouse Anti-Magoh
Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development This gene encodes the mammalian mago nashi homolog In mammals mRNA expression is not limited to the germ plasm but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts
£183.00
Transportin1 (TRN) Antibody- Mouse Anti-Transportin1
Heterogeneous nuclear ribonucleoprotein hnRNPA1 is an abundant nuclear protein that plays an important role in pre-mRNA processing and mRNA export from the nucleus A1 shuttles rapidly between the nucleus and the cytoplasm and a 38-amino acid domain M9 serves as the bi-directional transport signal of A1 Recently a 90-kD protein transportin was identified as the mediator of A1 nuclear import Transportin mediates the nuclear import of additional hnRNP proteins including hnRNPF The nuclear localization of A1 is dependent on ongoing RNA polymerase II transcription
£183.00
