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CCR9 Antibody - Rat Anti CCR9 1ml
The protein encoded by this gene is a member of the beta chemokine receptor family It is predicted to be a seven transmembrane protein similar to G protein coupled receptors Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions This gene is expressed in a range of tissues and hemopoietic cells The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors This receptor appears to bind the majority of beta-chemokine family members however its specific function remains unknown The specific ligand of this receptor is CCL25 It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract This gene is mapped to chromosome 3p213 a region that includes a cluster of chemokine receptor genes Two alternatively spliced transcript variants have been described
£226.00
MERTK Antibody- Mouse Anti-Mer Receptor Tyrosine Kinase
In vertebrates the photoreceptor cells are the basic sensory apparatus of the retina primarily converting photon energy absorbed from light into neuronal signals The photoreceptor proximal outer segments are synthesized daily by cell bodies and outer segment tips are removed with a circadian rhythm The shed outer segments are endocytosed by adjacent retinal pigment epithelial (RPE) cells and are recycled to photoreceptors The receptor tyrosine kinase MERTK protein is an approximately 120-122 kDa (994 amino acids) protein expressed in RPEs MERTK has a tyrosine kinase domain close to the C-terminal region and putative phosphorylation sites Mutation of MERTK in the Royal College of Surgeons (RCS) rat results in defective phagocytosis of photoreceptor outer segments by the retinal pigment epithelium (RPE) and retinal degeneration resulting in retinitis pigmentosa
£226.00
