Cell Cycle Antibodies for research into the Cell Cycle which has four distinct phases, G1, S, G2 and M collectively representing cell division which follows a highly regulated pathway culminating in mitosis in eukaryotes.
Cell cycle antibody research into disruption of the cell cycle has been implicated in tumour formation and growth, active cell division targeting in treating cancer and negative cardiovascular incidents.
Cell cycle antibodies are available in the following volumes including 0.05 ml, 0.1ml, 0.2 ml, 1 ml and 2 ml.
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hCAP-D3 Antibody ; Mouse Anti-hCAP-D3
Condensin complexes I and II play essential roles in mitotic chromosome assembly and segregation. Condensins contain 2 invariant structural maintenance of chromosome (SMC) subunits, SMC2 and SMC4. hCAP-D3 is a regulatory non-SMC subunit of the condensin II complex
£226.00
Mad2L1 Antibody- Mouse Anti-Mad2L1
Mad2L1 is required for the execution of the mitotic checkpoint which monitors the process of kinetochore spindle attachment and delays the onset of anaphase when this process is not complete It inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate
£183.00
Ndfip1 Antibody- Hamster Anti-Ndfip1
Ndfip1 belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins
£183.00
Ndfip1 Antibody- Hamster Anti-Ndfip1
Ndfip1 belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins
£226.00
NEK2 Antibody- Sheep Anti-NEK2
NEK2 is closely related in its catalytic domain to the serine/threonineprotein kinase NIMA of Aspergillus nidulans which is required for entry into mitosis and may function in parallel to the universal mitotic inducer p34cdc2. Like NIMA, the Nek2 protein is almost undetectable during G1 but accumulates progressively throughout S, reaching maximal levels in late G2. These observations demonstrate that NEK2 resembles Aspergillus NIMA, both in its catalytic domain, and cell cycle-dependent expression. Recombinant NEK2 is active as a serine/threonine-specific protein kinase and may undergo autophosphorylation. Both human NEK2 and fungal NIMA phosphorylate a similar, but not identical, set of proteins and synthetic peptides. NEK2 is shown to be expressed most abundantly in adult testis and there is increasing evidence that NEK2 is abnormally expressed in a wide variety of human cancers
£226.00
Nidogen/Enactin-G1 Domain Antibody- Rat Anti-Nidogen/Enactin-G1 Domain
Nidogen 1 / Entactin is a sulfated glycoprotein which is widely distributed in basement membranes and that is tightly associated with laminin Also binds to collagen IV It probably has a role in cell extracellular matrix interactions
£226.00
Nidogen/Enactin-G1 Domain Antibody- Rat Anti-Nidogen/Enactin-G1 Domain
Nidogen 1 / Entactin is a sulfated glycoprotein which is widely distributed in basement membranes and that is tightly associated with laminin Also binds to collagen IV It probably has a role in cell extracellular matrix interactions
£183.00
Nidogen/Enactin-G2 Domain Antibody- Rat Anti-Nidogen/Enactin-G2 Domain
Nidogen 1 / Entactin is a sulfated glycoprotein which is widely distributed in basement membranes and that is tightly associated with laminin Also binds to collagen IV It probably has a role in cell extracellular matrix interactions
£226.00
Nidogen/Enactin-G2 Domain Antibody- Rat Anti-Nidogen/Enactin-G2 Domain
Nidogen 1 / Entactin is a sulfated glycoprotein which is widely distributed in basement membranes and that is tightly associated with laminin Also binds to collagen IV It probably has a role in cell extracellular matrix interactions
£183.00
Nidogen/Enactin-G3 Domain Antibody- Rat Anti-Nidogen/Enactin-G3 Domain
Nidogen 1 / Entactin is a sulfated glycoprotein which is widely distributed in basement membranes and that is tightly associated with laminin Also binds to collagen IV It probably has a role in cell extracellular matrix interactions
£226.00
Nidogen/Enactin-G3 Domain Antibody- Rat Anti-Nidogen/Enactin-G3 Domain
Nidogen 1 / Entactin is a sulfated glycoprotein which is widely distributed in basement membranes and that is tightly associated with laminin Also binds to collagen IV It probably has a role in cell extracellular matrix interactions
£183.00
PP2A C-terminal
Functions in cell cycle control and growth factor signaling. PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. It can also dephosphorylate SV40 large T antigen and p53
£226.00
RanGEF (RCC1) Antibody- Rabbit Anti-RanGEF
Ran GTPase plays important roles in nucleocytoplasmic transport in interphase and in both spindle formation and nuclear envelope (NE) assembly during mitosis The latter functions rely on the presence of high local concentrations of GTP bound Ran near mitotic chromatin RanGTP localization has been proposed to result from the association of Rans GDP/GTP exchange factor RCC1 with chromatin but Ran is shown here to bind directly to chromatin in two modes either dependent or independent of RCC1 and where bound to increase the affinity of chromatin for NE membranes
£226.00
Serine Protease Inhibitor 2A (Spi2A) Antibody- Hamster Anti-Serine Protease Inhibitor 2A (Spi2A)
Spi2A is a serine and cysteine protease inhibitor It can inhibit lysosomal papain-like proteases including the cathepsins B G H K L and V It is ineffective against elastase granzyme A granzyme B or caspases 3 8 or 9 Inhibition of cytoplasmic cathepsin B following release from the lysosome may protect cells from apoptosis This may facilitate the survival of progenitor T-cells and the subsequent development of long term memory CD8 T-cells
£183.00
Serine Protease Inhibitor 2A (Spi2A) Antibody- Hamster Anti-Serine Protease Inhibitor 2A (Spi2A)
Spi2A is a serine and cysteine protease inhibitor It can inhibit lysosomal papain-like proteases including the cathepsins B G H K L and V It is ineffective against elastase granzyme A granzyme B or caspases 3 8 or 9 Inhibition of cytoplasmic cathepsin B following release from the lysosome may protect cells from apoptosis This may facilitate the survival of progenitor T-cells and the subsequent development of long term memory CD8 T-cells
£226.00
