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Aurora B Antibody - Sheep Anti- Aurora B 0.2ml
Aurora B is a mitotic protein kinase that phosphorylates histone H3 (probably on Serine 10) behaves as a chromosomal passenger protein and may regulate several stages of mitosis such as centrosome separation chromosome segregation and cytokinesis It localizes to the inner centromere region from prophase to anaphase
£226.00
ORC2 (origin recognition complex 2) Antibody- Rat Anti-ORC2
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins ORC2L is a subunit of the ORC complex ORC2L forms a core complex with ORC3L 4L and 5L It also interacts with CDC45L and MCM10 which are proteins known to be important for the initiation of DNA replication ORC2L specifically associate with the origin of replication of Epstein Barr virus in human cells and is thought to be required for DNA replication from viral origin of replication
£183.00
PP2A C Antibody ; Mouse Anti-PP2A C
PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen
£226.00
PPM1 (PP2A Methyltransferase)
Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues
£226.00
