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Mad1p Antibody- Rabbit Anti-Mad1p
MAD1 is a non-essential gene that encodes a component of the spindle checkpoint. The spindle checkpoint delays the onset of anaphase in cells with defects in mitotic spindle assembly or in the attachment of chromosomes to the spindle microtubules. The checkpoint works by inhibiting the activity of the anaphase promoting complex, thereby preventing the degradation of several cell cycle regulators. Like other spindle checkpoint mutants, MAD1 loss-of-function mutants are sensitive to benomyl and cannot delay cell division in response to spindle depolymerization. Mad1p becomes hyperphosphorylated upon spindle depolymerization
£226.00
Mad2p Antibody- Rabbit Anti-Mad2p
MAD2 is a non-essential gene that encodes a component of the spindle checkpoint. The spindle checkpoint delays the onset of anaphase in cells with defects in mitotic spindle assembly or in the attachment of chromosomes to the spindle microtubules. The checkpoint works by inhibiting the activity of the anaphase promoting complex, thereby preventing the degradation of several cell cycle regulators.hMAD2 is the human homologue of yeast MAD2
£226.00
Mus81 Antibody- Mouse Anti-Mus81
Reduction or loss of a protein called Mus81 can led to the development of lymphomas and other tumours in mice Mus81 is a protein long thought to be involved in repairing DNA that is damaged during normal metabolic processes
£183.00
ORC3 (origin recognition complex 3) Antibody- Rat Anti-ORC3
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins ORC3 is a subunit of the ORC complex Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory
£183.00
