Cell Division Checkpoint Proteins

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MCPH1 (BRIT1) Antibody- Mouse Anti-MCPH1 (BRIT1)

This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome MCPH1 looks like it might be a useful prognostic indicator in breast cancer associated with BRCA1 inactivation

£226.00

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ORC3 (origin recognition complex 3) Antibody- Rat Anti-ORC3

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins ORC3 is a subunit of the ORC complex Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory

£183.00

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