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MCPH1 (BRIT1) Antibody- Mouse Anti-MCPH1 (BRIT1)
This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome
MCPH1 looks like it might be a useful prognostic indicator in breast cancer associated with BRCA1 inactivation
£226.00
ORC1 (origin recognition complex 1) Antibody- Rat Anti-ORC1
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins The protein encoded by this gene is the largest subunit of the ORC complex While other ORC subunits are stable throughout the cell cycle the levels of this protein vary during the cell cycle which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication This protein is found to be selectively phosphorylated during mitosis It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1) a protein involved in control of transcription silencing
£183.00
ORC2 (origin recognition complex 2) Antibody- Rat Anti-ORC2
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins ORC2L is a subunit of the ORC complex ORC2L forms a core complex with ORC3L 4L and 5L It also interacts with CDC45L and MCM10 which are proteins known to be important for the initiation of DNA replication ORC2L specifically associate with the origin of replication of Epstein Barr virus in human cells and is thought to be required for DNA replication from viral origin of replication
£183.00
ORC3 (origin recognition complex 3) Antibody- Rat Anti-ORC3
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins ORC3 is a subunit of the ORC complex Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory
£183.00
ORC6 (origin recognition complex 6) Antibody- Rat Anti-ORC6
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins ORC6L is a subunit of the ORC complex It has been shown that ORC6L and and ORC1L are loosely associated with the core complex consisting of ORC2L 3L 4L and 5L Gene silencing studies with small interfering RNA demonstrated that ORC6L plays an essential role in coordinating chromosome replication and segregation with cytokinesis
£183.00
