DNA damage recognition antibodies are useful in understanding mechanisms related to DNA repair, sets of linked processes in which a cell interprets and actively trys to correct damage to the DNA molecules that encode the cell genome.
DNA damage recognition antibodies research help elucidate damage caused by stressors, environmental (eg UV light, radiation ) and metabolic (e.g. oxidative and alkylation) and a cells ability to repair in the face of what can be up to 1 million molecular cell lesions per day.
DNA damage is implicated in wide range of disease areas including cancer and tumour formation.
DNA damage recognition antibodies are available in the following volumes 0.05 ml, 0.1 ml, 0.2 ml, 0.5 ml, 1ml and 2 ml
Research Notes on DNA damage recognition antibodies are available
|
|
Eme1 (Msm4) Antibody- Mouse Anti-Eme1 (Msm4)
EME1 complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein (MUS81) to form an endonuclease complex which cleaves branched DNA structures, especially those arising during stalled DNA replication. The protein may be involved in repairing DNA damage and in maintaining genomic stability. It interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. Alternative splicing results in multiple transcript variants.
£183.00
MCPH1 (BRIT1) Antibody- Mouse Anti-MCPH1 (BRIT1)
This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome
MCPH1 looks like it might be a useful prognostic indicator in breast cancer associated with BRCA1 inactivation
£226.00
ORC1 (origin recognition complex 1) Antibody- Rat Anti-ORC1
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins The protein encoded by this gene is the largest subunit of the ORC complex While other ORC subunits are stable throughout the cell cycle the levels of this protein vary during the cell cycle which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication This protein is found to be selectively phosphorylated during mitosis It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1) a protein involved in control of transcription silencing
£183.00
ORC2 (origin recognition complex 2) Antibody- Rat Anti-ORC2
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins ORC2L is a subunit of the ORC complex ORC2L forms a core complex with ORC3L 4L and 5L It also interacts with CDC45L and MCM10 which are proteins known to be important for the initiation of DNA replication ORC2L specifically associate with the origin of replication of Epstein Barr virus in human cells and is thought to be required for DNA replication from viral origin of replication
£183.00
ORC3 (origin recognition complex 3) Antibody- Rat Anti-ORC3
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins ORC3 is a subunit of the ORC complex Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory
£183.00
ORC6 (origin recognition complex 6) Antibody- Rat Anti-ORC6
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins ORC6L is a subunit of the ORC complex It has been shown that ORC6L and and ORC1L are loosely associated with the core complex consisting of ORC2L 3L 4L and 5L Gene silencing studies with small interfering RNA demonstrated that ORC6L plays an essential role in coordinating chromosome replication and segregation with cytokinesis
£183.00
PARP2 Antibody- Goat Anti-PARP2
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.
£226.00
RNA polymerase II CTD Antibody- Mouse Anti-RNA polymerase II CTD
RNA polymerase II carboxy-terminal domain (CTD) interacts with a large multisubunit complex that contains TATA-binding protein (TBP) and is an integral part of the transcription initiation complex Phosphorylation of RNA polymerase IIs largest subunit C-terminal domain (CTD) is a key event during mRNA metabolism Numerous enzymes including cell cycle-dependent kinases and TFIIF-dependent phosphatases target the CTD
£183.00
RNA polymerase II CTD Antibody- Mouse Anti-RNA polymerase II CTD-phosphorylated
RNA polymerase II carboxy-terminal domain (CTD) interacts with a large multisubunit complex that contains TATA-binding protein (TBP) and is an integral part of the transcription initiation complex Phosphorylation of RNA polymerase IIs largest subunit C-terminal domain (CTD) is a key event during mRNA metabolism Numerous enzymes including cell cycle-dependent kinases and TFIIF-dependent phosphatases target the CTD
£183.00
