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Inherited Degenerative Disorders

Inheritance is a prime antecedent of many neurodegenerative disorders. Primarily these disorders result from a genetic mutation or imbalance, passed from parent to child.

With autosomal dominance disease, a parent with the trait will pass on that mutation to half there offspring with an equal split between male and female sibs. The disease type   for example Huntington’s is most characterised as vertical transmitted appearing with each generation.

With autosomal recessive diseases, for example Cystic Fibrosis, both parents while clinically asymptomatic, must pass in combination, the mutation on to 25 % of the offspring. This is called horizontal transmission.

In polygenic diseases there is an interaction between genetic and non genetic factors in what can be complex ways e.g. diabetes, heart disease and cancer.

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Primary Description:

Mouse Anti-Apolipoprotein E4 [4E4]

Product Reference Code: IQ552
Species Reactivity:

Human

Applications:

Dot blot, ELISA, WB, IP, flow cytometry

£226.00

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Immunocytochemistry/ Immunofluorescence - Anti-Emerin antibody at a 1/100 dilution
Primary Description:

Goat Anti-Emerin 

Product Reference Code: IQ323
Species Reactivity:

Mouse, Rat, Hamster, Human

Applications:

WB, ICC/IF

£226.00

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Immunocytochemistry/ Immunofluorescence - Anti-Emerin antibody at a 1/100 dilution
Primary Description:

Sheep Anti-Emerin 

Product Reference Code: IQ324
Species Reactivity:

Mouse, Rat, Hamster

Applications:

WB, ICC/IF, Electron Microscopy

£226.00

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Immunohistochemistry showing Anti-hnRNP C1+C2 on formalin fixed paraffin embedded breast tissue
Primary Description:

Mouse Anti-hnRNP C1+C2 [4F4]

Product Reference Code: IQ214
Species Reactivity:

Chicken, Hamster, Human, Monkey

Applications:

ICC/IF, IP, IHC-P, ELISA, WB

£226.00

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Immunohistochemistry of Anti-hnRNP C1+C2 on formalin fixed paraffin embedded breast tissue
Primary Description:

Mouse Anti-hnRNP C1+C2 [4F4]

Product Reference Code: IQ270
Species Reactivity:

Chicken, Hamster, Human, Monkey

Applications:

ICC/IF, IP, IHC-P, ELISA, WB

£183.00

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Western blot - Lamin A + C antibody [JoL5] - Nuclear Envelope Marker
Primary Description:

Mouse Anti-Lamin A + C antibody [JoL5] - Nuclear Envelope Marker

Product Reference Code: IQ252
Species Reactivity:

Mouse, Human

Applications:

ICC/IF, WB

£183.00

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Immunostaining reaction of lamin A antibody with human epidermis
Primary Description:

Mouse Anti-Lamin A [133A2]

Product Reference Code: IQ248
Species Reactivity:

Mouse, Rat, Cow, Dog, Human, Monkey

Applications:

Flow Cyt, IHC-Fr, WB, IHC-P, ICC/IF, IP

£183.00

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Lamin expression in basal cell skin carcinomas. Frozen sections stained with Lamin A antibody [JOL4]
Primary Description:

Mouse Anti-Lamin A [JOL4]

Product Reference Code: IQ330
Species Reactivity:

Human, Mouse

Applications:

IF, IHC(Fr), IP, WB

£183.00

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Immunohistochemistry of Anti-Lamin A+C on formalin fixed paraffin embedded skin tissue
Primary Description:

Mouse Anti-Lamin A+C [JOL2]

Product Reference Code: IQ332
Species Reactivity:

Human, African Green Monkey

Applications:

ICC/IF, IHC-Fr, IHC-P, WB, IP, Flow Cyt

£199.00

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Immunocytochemistry/ Immunofluorescence - Lamin A + C antibody [JoL3] - Nuclear Envelope Marker
Primary Description:

Mouse Anti-Lamin A + C antibody [JoL3] - Nuclear Envelope Marker

Product Reference Code: IQ251
Species Reactivity:

Mouse, Rat, Human

Applications:

WB, ICC/IF

£183.00

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Confocal optical section, green is FITC (lamin A/C [JOL3]) and blue is DAPI (DNA). Cells were fixed in 4% paraformaldehyde in PEM buffer then extracted with 0.5% Triton X-100 before labelling with JOL3-FITC.
Primary Description:

Mouse Anti-Lamin A/C [JOL3]: FITC

Product Reference Code: IQ656FITC
Species Reactivity:

Human, Mouse, Rat

Applications:

ICC/IF

£245.00

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Immunocytochemistry - Lamin B1 + B2 antibody [X223] - Nuclear Envelope Marker
Primary Description:

Mouse Anti-Lamin B1 + B2 antibody [X223] - Nuclear Envelope Marker

Product Reference Code: IQ176
Species Reactivity:

Mouse, Rat, Cow, Human

Applications:

ICC/IF, WB 

£226.00

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Immunohistochemistry of lamin B1 antibody [119D5-F1] - Nuclear Envelope Marker on human epidermis
Primary Description:

Mouse Anti-Lamin B1 [119D5-F1] - Nuclear Envelope Marker

Product Reference Code: IQ249
Species Reactivity:

Mouse, Rat, Sheep, Rabbit, Cow, Dog, Human, Zebrafish

Applications:

WB, Dot Blot, ELISA, Flow Cyt, ICC/IF, IHC, IP

£183.00

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Immunohistochemistry showing Lamin C on formalin fixed paraffin embedded skin tissue at 1:100
Primary Description:

Rabbit Anti-Lamin C

Product Reference Code: IQ177
Species Reactivity:

Human, Mouse, Rat 

Applications:

ICC/IF, IHC-P, IHC-Fr, WB, Flow

£226.00

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Primary Description:

Rabbit Anti-LAP2 alpha

Product Reference Code: IQ175
Species Reactivity:

Mouse, Rat, Human

Applications:

ChIP, IP, ICC/IF, WB

£226.00

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Human dermal fibroblasts (HDF), stained Nesprin-1 C1 (1:100). Methanol/Acetone (1:1) fixed the cells
Primary Description:

Rabbit Anti-Nesprin 1

Product Reference Code: IQ171
Species Reactivity:

Mouse, Human

Applications:

IHC (PFA fixed), WB, ICC/IF, IHC-Fr

£226.00

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