Inheritance is a prime antecedent of many neurodegenerative disorders. Primarily these disorders result from a genetic mutation or imbalance, passed from parent to child.
With autosomal dominance disease, a parent with the trait will pass on that mutation to half there offspring with an equal split between male and female sibs. The disease type for example Huntington’s is most characterised as vertical transmitted appearing with each generation.
With autosomal recessive diseases, for example Cystic Fibrosis, both parents while clinically asymptomatic, must pass in combination, the mutation on to 25 % of the offspring. This is called horizontal transmission.
In polygenic diseases there is an interaction between genetic and non genetic factors in what can be complex ways e.g. diabetes, heart disease and cancer.
Primary Description: | Mouse Anti-Apolipoprotein E4 [4E4] |
Product Reference Code: | IQ552 |
Species Reactivity: | Human |
Applications: | Dot blot, ELISA, WB, IP, flow cytometry |
Primary Description: | Goat Anti-Emerin |
Product Reference Code: | IQ323 |
Species Reactivity: | Mouse, Rat, Hamster, Human |
Applications: | WB, ICC/IF |
Primary Description: | Sheep Anti-Emerin |
Product Reference Code: | IQ324 |
Species Reactivity: | Mouse, Rat, Hamster |
Applications: | WB, ICC/IF, Electron Microscopy |
Primary Description: | Mouse Anti-hnRNP C1+C2 [4F4] |
Product Reference Code: | IQ214 |
Species Reactivity: | Chicken, Hamster, Human, Monkey |
Applications: | ICC/IF, IP, IHC-P, ELISA, WB |
Primary Description: | Mouse Anti-hnRNP C1+C2 [4F4] |
Product Reference Code: | IQ270 |
Species Reactivity: | Chicken, Hamster, Human, Monkey |
Applications: | ICC/IF, IP, IHC-P, ELISA, WB |
Primary Description: | Mouse Anti-Lamin A + C antibody [JoL5] - Nuclear Envelope Marker |
Product Reference Code: | IQ252 |
Species Reactivity: | Mouse, Human |
Applications: | ICC/IF, WB |
Primary Description: | Mouse Anti-Lamin A [JOL4] |
Product Reference Code: | IQ330 |
Species Reactivity: | Human, Mouse |
Applications: | IF, IHC(Fr), IP, WB |
Primary Description: | Mouse Anti-Lamin A+C [JOL2] |
Product Reference Code: | IQ332 |
Species Reactivity: | Human, African Green Monkey |
Applications: | ICC/IF, IHC-Fr, IHC-P, WB, IP, Flow Cyt |
Primary Description: | Mouse Anti-Lamin A + C antibody [JoL3] - Nuclear Envelope Marker |
Product Reference Code: | IQ251 |
Species Reactivity: | Mouse, Rat, Human |
Applications: | WB, ICC/IF |
Primary Description: | Mouse Anti-Lamin A/C [JOL3]: FITC |
Product Reference Code: | IQ656FITC |
Species Reactivity: | Human, Mouse, Rat |
Applications: | ICC/IF |
Primary Description: | Mouse Anti-Lamin B1 + B2 antibody [X223] - Nuclear Envelope Marker |
Product Reference Code: | IQ176 |
Species Reactivity: | Mouse, Rat, Cow, Human |
Applications: | ICC/IF, WB |
Primary Description: | Rabbit Anti-Lamin C |
Product Reference Code: | IQ177 |
Species Reactivity: | Human, Mouse, Rat |
Applications: | ICC/IF, IHC-P, IHC-Fr, WB, Flow |
Primary Description: | Rabbit Anti-LAP2 alpha |
Product Reference Code: | IQ175 |
Species Reactivity: | Mouse, Rat, Human |
Applications: | ChIP, IP, ICC/IF, WB |
Primary Description: | Mouse Anti-PP2A alpha [2G9] |
Product Reference Code: | IQ548 |
Species Reactivity: | Human, Mouse, Rat. Predicted to react with Porcine, Rabbit, Chicken, Xenopus |
Applications: | WB, IP |