T Cells, thymus cells, are the key to the adapted cell immune response and responses thereof. T Cells indentify foreign antigens to eliminate specific pathogens. Once identified T Cells produce either helper cells which manufacture cytokines to help target highly the specific bacteria or virus or manufacture cytotoxic T cells that produce toxic enzymatic granules that induce pathogen infected cell death.
Post response, one consequent benefit to the organism is a memory effect whereby the antibody response pathway is now pre-programmed. In the event of any future infection or pathogenic invasion the memory effect encourages a swifter and dictated response.
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Ca19.9 Sialyl Lewis a Antibody - Mouse Anti-Ca19.9 Sialyl Lewis a
Mucin glucoprotein is a sialyl Lewisa structure which is synthesized from type 1 blood group precursor chains and is present in individuals expressing the Lewisa and/or Lewisb blood group antigens. In normal tissues, sialyl Lewisa antigen is present in ductal epithelium of the breast, kidney, salivary gland, and sweat glands. Its expression is greatly enhanced in serum as well as in the majority of tumor cells in gastrointestinal (GI) carcinomas
£226.00
CCR9 Antibody - Rat Anti CCR9 1ml
The protein encoded by this gene is a member of the beta chemokine receptor family It is predicted to be a seven transmembrane protein similar to G protein coupled receptors Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions This gene is expressed in a range of tissues and hemopoietic cells The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors This receptor appears to bind the majority of beta-chemokine family members however its specific function remains unknown The specific ligand of this receptor is CCL25 It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract This gene is mapped to chromosome 3p213 a region that includes a cluster of chemokine receptor genes Two alternatively spliced transcript variants have been described
£226.00
DO-11.10 T cell Receptor Antibody- Mouse Anti- DO-11.10 T cell Receptor
The KJ1-26 anti-idiotypic monoclonal antibody binds the T-cell receptor (TCR) expressed on DO11.10 and DO11.10.24 murine T cell hybridomas, but not on any other T cell hybridomas tested.The TCR expressed on DO11.10 recognizes an ovalbumin peptide in the context of I-Ad major histocompatibility molecules.The use of DO11.10 and KJ1-26 have proven to be instrumental in describing many of the intricate details of T cell immunity
£226.00
Histidine Tag Antibody- Mouse Anti-His Tag
The H-H-H-H-H-H motif is used as a tag on many recombinant proteins to facilitate purification The antibody recognizes the His-tag fused to the amino- or carboxy- termini of targeted proteins in transfected or transformed cells The antibody may be used to track the purification of proteins expressed in bacteria yeast or insect cells In Western blotting of bacterial extracts clone ADII10 has been shown not to cross react with any endogenous products although some cross reactivity may be seen with extracts of insect or mammalian cells
£226.00
HIV-2 Nef Antibody- Rat Anti-HIV-2 Nef
Nef is a multifunctional protein of 27 kDa in HIV1 and 35 kDa in HIV2 It induces the endocytosis of CD4 Receptor and reduces the MHC1 Receptors Thereby it enhances viral infectivity and affects T-cell signalling
£226.00
Ndfip1 Antibody- Hamster Anti-Ndfip1
Ndfip1 belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins
£183.00
Ndfip1 Antibody- Hamster Anti-Ndfip1
Ndfip1 belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins
£226.00
PDE3A Antibody- Rabbit Anti- Phosphodiesterase 3A
Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolytic inactivation of the common intracellular second messengers cyclic adenosine and guanosine 3 5-monophosphate (cAMP and cGMP) Thus these enzymes play a critical role in the regulation of a wide range of physiological processes modulated by cyclic nucleotide signalling The PDE3 enzyme belongs to a family of PDEs known as cGMP-inhibited PDEs The enzymes bind both cGMP and cAMP with different affinities The PDE3 family is comprised of two genes PDE3A and PDE3B
£226.00
Serine Protease Inhibitor 2A (Spi2A) Antibody- Hamster Anti-Serine Protease Inhibitor 2A (Spi2A)
Spi2A is a serine and cysteine protease inhibitor It can inhibit lysosomal papain-like proteases including the cathepsins B G H K L and V It is ineffective against elastase granzyme A granzyme B or caspases 3 8 or 9 Inhibition of cytoplasmic cathepsin B following release from the lysosome may protect cells from apoptosis This may facilitate the survival of progenitor T-cells and the subsequent development of long term memory CD8 T-cells
£183.00
Serine Protease Inhibitor 2A (Spi2A) Antibody- Hamster Anti-Serine Protease Inhibitor 2A (Spi2A)
Spi2A is a serine and cysteine protease inhibitor It can inhibit lysosomal papain-like proteases including the cathepsins B G H K L and V It is ineffective against elastase granzyme A granzyme B or caspases 3 8 or 9 Inhibition of cytoplasmic cathepsin B following release from the lysosome may protect cells from apoptosis This may facilitate the survival of progenitor T-cells and the subsequent development of long term memory CD8 T-cells
£226.00
T cell receptor Alpha + Beta Antibody- Mouse Anti-T cell receptor Alpha + Beta
The receptors on T cells consist of immunoglobulin like integral membrane glycoproteins containing 2 polypeptide subunits alpha and beta of similar molecular weight 40 to 55 kD in the human Like the immunoglobulins of the B cells each T cell receptor subunit has external to the cell membrane an N terminal variable domain and a C terminal constant domain T cell receptors recognise foreign antigens which have been processed as small peptides and bound to major histocompatibility complex molecules at the surface of antigen presenting cells Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain In a single cell the T cell receptor loci are rearranged and expressed in the order delta gamma beta and alpha If both delta and gamma rearrangements produce functional chains the cell expresses delta and gamma If not the cell proceeds to rearrange the beta and alpha loci
£226.00
