Serine Protease Inhibitor 2A (Spi2A) Antibody- Hamster Anti-Serine Protease Inhibitor 2A (Spi2A)
Spi2A is a serine and cysteine protease inhibitor It can inhibit lysosomal papain-like proteases including the cathepsins B G H K L and V It is ineffective against elastase granzyme A granzyme B or caspases 3 8 or 9 Inhibition of cytoplasmic cathepsin B following release from the lysosome may protect cells from apoptosis This may facilitate the survival of progenitor T-cells and the subsequent development of long term memory CD8 T-cells