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Inherited Diseases Nuclear Envelope

The nuclear envelope is a thin membrane that surrounds the genetic material in eukaryotic cells. It consists of a double layer of lipids, separating the nucleus content, principally DNA, from the surrounding cell cytoplasm.

The outer part of the nuclear envelope membrane is rough endoplasmic reticulum spotted as it is with ribosomes. The inner part consists of flat membrane proteins e.g. Emerin which are linked to the nuclear lamina and mutations in Lamins A and B.

The nuclear envelope is perforated with pores which enable the transport of proteins and RNA between the nucleus and cytoplasm. The inner and outer membranes conjoin at each nuclear pore site.

Nuclear envelope diseases or envelopathies impacted include muscular dystrophy and diabetes.

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Immunocytochemistry/ Immunofluorescence - Anti-Emerin antibody at a 1/100 dilution
Primary Description:

Goat Anti-Emerin 

Product Reference Code: IQ323
Species Reactivity:

Mouse, Rat, Hamster, Human

Applications:

WB, ICC/IF

£226.00

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Immunocytochemistry/ Immunofluorescence - Anti-Emerin antibody at a 1/100 dilution
Primary Description:

Sheep Anti-Emerin 

Product Reference Code: IQ324
Species Reactivity:

Mouse, Rat, Hamster

Applications:

WB, ICC/IF, Electron Microscopy

£226.00

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Immunocytochemistry/ Immunofluorescence - GP210 antibody on formaldehyde fixed HeLa cells
Primary Description:

Rabbit Anti-gp210 

Product Reference Code: IQ244
Species Reactivity:

Human, Rat, Xenopus laevis. Predicted to work with all Mammals

Applications:

WB, ICC/IF

£226.00

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Methanol/acetone fixed HeLa cells stained with rabbit anti gp210
Primary Description:

Rabbit Anti-gp210 

Product Reference Code: IQ294
Species Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ICC/IF, WB

£226.00

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Western blot - Lamin A + C antibody [JoL5] - Nuclear Envelope Marker
Primary Description:

Mouse Anti-Lamin A + C antibody [JoL5] - Nuclear Envelope Marker

Product Reference Code: IQ188
Species Reactivity:

Mouse, Human

Applications:

ICC/IF, WB

£226.00

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Western blot - Lamin A + C antibody [JoL5] - Nuclear Envelope Marker
Primary Description:

Mouse Anti-Lamin A + C antibody [JoL5] - Nuclear Envelope Marker

Product Reference Code: IQ252
Species Reactivity:

Mouse, Human

Applications:

ICC/IF, WB

£183.00

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Immunostaining reaction of lamin A antibody with human epidermis
Primary Description:

Mouse Anti-Lamin A [133A2]

Product Reference Code: IQ248
Species Reactivity:

Mouse, Rat, Cow, Dog, Human, Monkey

Applications:

Flow Cyt, IHC-Fr, WB, IHC-P, ICC/IF, IP

£183.00

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Lamin expression in basal cell skin carcinomas. Frozen sections stained with Lamin A antibody [JOL4]
Primary Description:

Mouse Anti-Lamin A [JOL4]

Product Reference Code: IQ330
Species Reactivity:

Human, Mouse

Applications:

IF, IHC(Fr), IP, WB

£183.00

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Immunohistochemistry of Anti-Lamin A+C on formalin fixed paraffin embedded skin tissue
Primary Description:

Mouse Anti-Lamin A+C [JOL2]

Product Reference Code: IQ332
Species Reactivity:

Human, African Green Monkey

Applications:

ICC/IF, IHC-Fr, IHC-P, WB, IP, Flow Cyt

£199.00

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Immunocytochemistry/ Immunofluorescence - Lamin A + C antibody [JoL3] - Nuclear Envelope Marker
Primary Description:

Mouse Anti-Lamin A + C antibody [JoL3] - Nuclear Envelope Marker

Product Reference Code: IQ251
Species Reactivity:

Mouse, Rat, Human

Applications:

WB, ICC/IF

£183.00

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Primary Description:

Mouse Anti-Lamin A+C R453W [12A-2F5]

Product Reference Code: IQ541
Species Reactivity:

Human

Applications:

WB, IP, ICC/IF

£226.00

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Immunocytochemistry - Lamin B1 + B2 antibody [X223] - Nuclear Envelope Marker
Primary Description:

Mouse Anti-Lamin B1 + B2 antibody [X223] - Nuclear Envelope Marker

Product Reference Code: IQ176
Species Reactivity:

Mouse, Rat, Cow, Human

Applications:

ICC/IF, WB 

£226.00

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Immunohistochemistry of lamin B1 antibody [119D5-F1] - Nuclear Envelope Marker on human epidermis
Primary Description:

Mouse Anti-Lamin B1 [119D5-F1] - Nuclear Envelope Marker

Product Reference Code: IQ249
Species Reactivity:

Mouse, Rat, Sheep, Rabbit, Cow, Dog, Human, Zebrafish

Applications:

WB, Dot Blot, ELISA, Flow Cyt, ICC/IF, IHC, IP

£183.00

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Immunostaining reaction of lamin B2 antibody [LN43] with human epidermis
Primary Description:

Mouse Anti-Lamin B2 [LN43] - Nuclear Envelope Marker

Product Reference Code: IQ250
Species Reactivity:

 Mouse, Hamster, Human, Xenopus laevis, Zebrafish

Applications:

ICC/IF, Flow Cyt, IHC-Fr, WB, IP

£183.00

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Immunohistochemistry showing Lamin C on formalin fixed paraffin embedded skin tissue at 1:100
Primary Description:

Rabbit Anti-Lamin C

Product Reference Code: IQ177
Species Reactivity:

Human, Mouse, Rat 

Applications:

ICC/IF, IHC-P, IHC-Fr, WB, Flow

£226.00

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Human dermal fibroblasts (HDF), stained Nesprin-1 C1 (1:100). Methanol/Acetone (1:1) fixed the cells
Primary Description:

Rabbit Anti-Nesprin 1

Product Reference Code: IQ171
Species Reactivity:

Mouse, Human

Applications:

IHC (PFA fixed), WB, ICC/IF, IHC-Fr

£226.00

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