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Clostridium botulinus - Rabbit Anti-Clostridium botulinus
Clostridium botulinum neurotoxins are zinc-dependent proteases that block the release of acetylcholine from peripheral cholinergic nerve endings by targeting specific membrane proteins including synaptosomal-associated proteins (SNAP), vesicle-associated membrane proteins (VAMP), and syntaxins. Neurotoxin A is characteristically associated with human botulism and known to target and hydrolyse the 197-Gln-|-Arg-198 bond of SNAP-25
£226.00
HIV-1 Vif Antibody- Mouse Anti-HIV-1 Vif
HIV1 Vif (viral infectivity factor), supports productive viral replication in non-permissive cells, such as peripheral blood lymphocytes. It functions by inactivating a cellular anti-viral factor named APOBEC3G.Vif binds viral RNA and affects the stability of viral nucleoprotein core. May play a role in viral morphology. Interacts with host ABCE1, which seems to be involved in lentiviruses capsid formation and displays RNase L inhibitor activity. This interaction may play a role in protecting viral RNA from damage during viral assembly
£226.00
HIV-2 Nef Antibody- Rat Anti-HIV-2 Nef
Nef is a multifunctional protein of 27 kDa in HIV1 and 35 kDa in HIV2 It induces the endocytosis of CD4 Receptor and reduces the MHC1 Receptors Thereby it enhances viral infectivity and affects T-cell signalling
£226.00
HIV1 integrase Antibody- Mouse Anti-HIV1 integrase
Integrase is an enzyme, a product of the HIV1 Gag/Pol gene; the other two enzymes being reverse transcriptase and protease. The human immunodeficiency virus (HIV-1) uses an enzyme, a so-called integrase, to carry out the integration of its viral DNA into the host chromosome thereby tricking the host cell machinery into making viral proteins. The HIV-1 integrase is a protein of 32 kDa and is composed of three domains. No cellular homologue of HIV integrase has been described, so potential inhibitors to this enzyme could be relatively nontoxic.
£226.00
HIV1 P17 Gag Antibody- Mouse Anti-HIV1 P17 Gag
HIV1 p17 is the matrix protein of the Gag polyprotein which performs highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA
£226.00
Influenza A Nucleoprotein Antibody- Mouse Anti-Influenza A
The nucleoprotein (NP) of Influenza virus encapsulates the negative strand of the viral RNA and is essential for replicative transcription. It may also be involved in other essential functions throughout the virus life cycle. As well as binding ssRNA, NP is able to self associate to form large oligomeric complexes. NP is able to interact with a variety of other macromolecules of both viral and cellular origins. It binds the PB1 and PB2 subunits of the polymerase and the matrix protein M1. "NP has also been shown to interact with at least four cellular polypeptide families: nuclear import receptors of the importin class, filamentous (F) actin, the nuclear export receptor CRM1 and a DEAD box helicase BAT1/UAP56" (Portela et al 2002).
£226.00
Influenza B Virus Nucleoprotein Antibody- Mouse Anti-Influenza B Nucleoprotein
Influenza virus B is a genus in the virus family Orthomyxoviridae. A limited host range means that Influenza virus B pandemics are rare.The nucleoprotein protects the negative strand viral RNA from nucleases by encapsidating it. encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication
£226.00
Legionella pneumophila Antibody- Mouse Anti-Legionella pneumophila
Legionella pneumophila is a flagellated gram negative bacterium found primarily in warm water environments Legionella pneumophila causes a type of pneumonia called Legionnaire disease and a milder condition called Pontiac fever Infection is acquired through inhalation of the microorganism in water mists (eg from air conditioning cooling towers whirlpool spas and showers mists) A number of risk factors for acquiring Legionnaire disease have been identified including age smoking chronic lung disease cancer and immunosuppression
£226.00
MRSA Antibody- Mouse Anti-MRSA
Methicillin-resistant Staphylococcus Aureus (MRSA) is a type of bacteria that is resistant to certain antibiotics These antibiotics include methicillin and other more common antibiotics such as oxacillin penicillin and amoxicillin Staphylococcus infections including MRSA occur most frequently among persons in hospitals and healthcare facilities (such as nursing homes and dialysis centres) who have weakened immune systems
£226.00
Nidogen/Enactin-G1 Domain Antibody- Rat Anti-Nidogen/Enactin-G1 Domain
Nidogen 1 / Entactin is a sulfated glycoprotein which is widely distributed in basement membranes and that is tightly associated with laminin Also binds to collagen IV It probably has a role in cell extracellular matrix interactions
£226.00
Nidogen/Enactin-G1 Domain Antibody- Rat Anti-Nidogen/Enactin-G1 Domain
Nidogen 1 / Entactin is a sulfated glycoprotein which is widely distributed in basement membranes and that is tightly associated with laminin Also binds to collagen IV It probably has a role in cell extracellular matrix interactions
£183.00
Nidogen/Enactin-G2 Domain Antibody- Rat Anti-Nidogen/Enactin-G2 Domain
Nidogen 1 / Entactin is a sulfated glycoprotein which is widely distributed in basement membranes and that is tightly associated with laminin Also binds to collagen IV It probably has a role in cell extracellular matrix interactions
£226.00
Nidogen/Enactin-G3 Domain Antibody- Rat Anti-Nidogen/Enactin-G3 Domain
Nidogen 1 / Entactin is a sulfated glycoprotein which is widely distributed in basement membranes and that is tightly associated with laminin Also binds to collagen IV It probably has a role in cell extracellular matrix interactions
£226.00
Nidogen/Enactin-G3 Domain Antibody- Rat Anti-Nidogen/Enactin-G3 Domain
Nidogen 1 / Entactin is a sulfated glycoprotein which is widely distributed in basement membranes and that is tightly associated with laminin Also binds to collagen IV It probably has a role in cell extracellular matrix interactions
£183.00
PDE4D Antibody- Rabbit Anti- Phosphodiesterase 4D
Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolytic inactivation of the common intracellular second messengers cyclic adenosine and guanosine 3 5-monophosphate (cAMP and cGMP) Thus these enzymes play a critical role in the regulation of a wide range of physiological processes modulated by cyclic nucleotide signalling The PDE5 enzyme belongs to a family of cGMP-dependent PDEs that provide the major means of inactivating the key intracellular second messenger cGMP
£226.00
Penicillin Antibody- Mouse Anti-Penicillin
Penicillin is a group of Beta-lactam antibiotics used in the treatment of bacterial infections caused by susceptible usually Gram-positive organisms -lactam antibiotics work by inhibiting the formation of peptidoglycan cross-links in the bacterial cell wall which results in cytolysis
£226.00
