Influenza or flu is an RNA virus which is the instigator of infectious disease response in birds and mammals. Typically transmitted via an aerosol effect flu is highly contagious and responsible for many human deaths per year.
Influenza viruses are categorised into A, B and C types. Type A serotypes e.g. H5N1 et al are typically hosted in birds and are highly virulent and frequently pass into human population quite often via infected poultry. Type B is rarer than A, and is almost always is implicated in human related infection. Type B mutates less slowly than A and therefore confers a degree of immunity. Type C is rarer still, infects humans and other species and overall causes mild infections only in human hosts.
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Influenza A Nucleoprotein Antibody- Mouse Anti-Influenza A
The nucleoprotein (NP) of Influenza virus encapsulates the negative strand of the viral RNA and is essential for replicative transcription. It may also be involved in other essential functions throughout the virus life cycle. As well as binding ssRNA, NP is able to self associate to form large oligomeric complexes. NP is able to interact with a variety of other macromolecules of both viral and cellular origins. It binds the PB1 and PB2 subunits of the polymerase and the matrix protein M1. "NP has also been shown to interact with at least four cellular polypeptide families: nuclear import receptors of the importin class, filamentous (F) actin, the nuclear export receptor CRM1 and a DEAD box helicase BAT1/UAP56" (Portela et al 2002).
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Influenza B Virus Nucleoprotein Antibody- Mouse Anti-Influenza B Nucleoprotein
Influenza virus B is a genus in the virus family Orthomyxoviridae. A limited host range means that Influenza virus B pandemics are rare.The nucleoprotein protects the negative strand viral RNA from nucleases by encapsidating it. encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication
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