Neuroscience focuses effort on understanding the mechanisms and processes of the nervous system. Immuquest offers a comprehensive range of neuroscience antibodies in this rapidly growing and multidisciplinary area of research.
Neuroscience antibodies available cover research areas including cytokeratins, neurotransmitters, cell checkpoint arrestor processes, et al
Neuroscience antibodies are available in the following volumes including 0.05 ml, 0.1ml, 0.2 ml, 1 ml and 2 ml.
Research Notes on neuroscience antibodies are available
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Apolipoprotein E4 Antibody ; Mouse Anti-Apolipoprotein E4
Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents.ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Individuals heterozygous for the ApoE4 allele are at higher risk of late-onset Alzheimer's disease. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased levels of plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants
£226.00
Cytokeratin (keratin) K2 (AE3) Antibody- Mouse Anti-Cytokeratin (keratin) K2 (AE3)
Cytokeratins, a group of at least 29 different proteins, are characteristic of epithelial and trichocytic cells. Cytokeratins 4, 5, 6 and 8 are members of the type II neutral-to-basic subfamily. Cytokeratin peptide 4 (59 kDa) is the secondary type II keratin expressed in non cornified stratified squamous epithelia. Cytokeratin peptide 5 (58 kDa) is the primary type II keratin in stratified epithelia, while cytokeratin type 8 (52 kDa) is a major type II keratin in simple epithelia. Cytokeratin 6 (56 kDa) is a "hyperproliferation" cytokeratin expressed in tissues with natural or pathological high turnover. Cytokeratins 10, 13 and 18 are members of the type I acidic subfamily. Cytokeratin peptide 10 (56 kDa) is the secondary type I keratin expressed in cornified epithelia. Cytokeratin 13 (54 kDa) is the secondary type I keratin expressed in non-cornified stratified squamous epithelia. Cytokeratin 18 (45 kDa) is the primary type I keratin expressed in simple epithelial cells.
£226.00
MCPH1 (BRIT1) Antibody- Mouse Anti-MCPH1 (BRIT1)
This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome
MCPH1 looks like it might be a useful prognostic indicator in breast cancer associated with BRCA1 inactivation
£226.00
Ndfip1 Antibody- Hamster Anti-Ndfip1
Ndfip1 belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins
£183.00
Nestin Antibody- Mouse Anti-Nestin
Nestin is a Class VI intermediate filament expressed in the developing central nervous system (CNS) in early embryonic neuroepithelial stem cells This protein has been widely used as a predominant marker for stem / progenitor cells glioma cells and tumor endothelial cells in the mammalian CNS Furthermore it is a superior angiogenic marker to evaluate neovascularity of endothelial cells in tumor This highly specific antibody to human nestin can aid in characterizing progenitor cells differentiating into distinct lineages in enhancing the therapeutic potential of human neural stem/progenitor cells in the treatment of CNS diseases or injury and in identifying neuroepithelial tumor cells
£183.00
Neurocan Antibody- Mouse Anti-Neurocan
Neurocan is the major soluble chondroitin sulfate proteoglycan in the brain It is thought to play a functional role in axonal growth and guidance and in the establishment of specific neural pathways during embryonic brain development Neurocan expression in the brain is developmentally regulated Early on the major form of neurocan consists of a 245kD core protein with approximately two chondroitin sulfate glycosoaminoglycan chains of 22kD each Later neurocan comprises a 180kD core protein Both forms of neurocan contain only chondroitin 4-sulfate glycosoaminoglycan chains By virtue of their high expression at sites of neural damage and trauma chondroitin sulfate proteoglycans including neurocan are thought to inhibit successful nerve regeneration
£183.00
NeurocanAntibody - Mouse Anti-Neurocan
Neurocan is the major soluble chondroitin sulfate proteoglycan in the brain It is thought to play a functional role in axonal growth and guidance and in the establishment of specific neural pathways during embryonic brain development Neurocan expression in the brain is developmentally regulated Early on the major form of neurocan consists of a 245kD core protein with approximately two chondroitin sulfate glycosoaminoglycan chains of 22kD each Later neurocan comprises a 180kD core protein Both forms of neurocan contain only chondroitin 4-sulfate glycosoaminoglycan chains By virtue of their high expression at sites of neural damage and trauma chondroitin sulfate proteoglycans including neurocan are thought to inhibit successful nerve regeneration
£226.00
NOX2/gp91phox Antibody- Mouse Anti-gp91phox
NOX2/gp91phox is a critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. It also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. Defects in CYBB are a cause of X-linked chronic granulomatous disease (X-CGD). X-CGD is characterized by the failure of activated phagocytes to generate superoxide. Patients suffer from life-threatening bacterial/fungal infections
£226.00
NOX2/gp91phox Antibody- Mouse Anti-gp91phox
NOX2/gp91phox is a critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. It also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. Defects in CYBB are a cause of X-linked chronic granulomatous disease (X-CGD). X-CGD is characterized by the failure of activated phagocytes to generate superoxide. Patients suffer from life-threatening bacterial/fungal infections
£226.00
NOX2/gp91phox Antibody- Mouse Anti-gp91phox
NOX2/gp91phox is a critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. It also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. Defects in CYBB are a cause of X-linked chronic granulomatous disease (X-CGD). X-CGD is characterized by the failure of activated phagocytes to generate superoxide. Patients suffer from life-threatening bacterial/fungal infections
£226.00
PP2A B´/B56 delta Antibody ; Mouse Anti-PP2A B´/B56 delta
PP2A is a heterotrimeric phosphatase, ccomposed of A, B and C subunits. The structural A and catalytic C subunits form the constitutive core of the enzyme, which associates with one of a large number of regulatory B subunits. Three families of B subunits have been identified thus far. The prototypical B (or PR55) family of subunits is encoded by three genes, Balpha, Bbeta and Bgamma . The B' (or B56) family consists of at least seven splice variantsderived from five genes. RNA's for the two members of the B'' family, PR72 and PR130, arise by alternative splicing or use of alternate transcription start sites from the same gene. Primary structures as well as functions of B and B' subunits are conserved from yeast to mammals
£226.00
PP2A C-terminal
Functions in cell cycle control and growth factor signaling. PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. It can also dephosphorylate SV40 large T antigen and p53
£226.00
Receptor Tyrosine Phosphatase Beta (phosphacan) Antibody- Mouse Anti-Receptor Tyrosine Phosphatase Beta (phosphacan)
PTPRB is a member of the protein tyrosine phosphatase (PTP) family The family comprises at least 37 proteins characterized by a catalytic phosphatase domain of approximately 240 amino acids and includes both transmembrane and cytosolic enzymes PTP1B is a transmembrane PTP The PTPs have high substrate specificity for phosphotyrosyl proteins at the primary sequence level sharing little similarity with the protein serine phosphatases protein threonine phosphatases or the acid and alkaline phosphatases PTP beta interacts with and regulates the tyrosine phosphorylation level of catenins which are critical in physiological and pathological events such as cell migration adhesion and transformation
£183.00
Receptor Tyrosine Phosphatase Beta (phosphacan) Antibody- Mouse Anti-Receptor Tyrosine Phosphatase Beta (phosphacan)
PTPRB is a member of the protein tyrosine phosphatase (PTP) family The family comprises at least 37 proteins characterized by a catalytic phosphatase domain of approximately 240 amino acids and includes both transmembrane and cytosolic enzymes PTP1B is a transmembrane PTP The PTPs have high substrate specificity for phosphotyrosyl proteins at the primary sequence level sharing little similarity with the protein serine phosphatases protein threonine phosphatases or the acid and alkaline phosphatases PTP beta interacts with and regulates the tyrosine phosphorylation level of catenins which are critical in physiological and pathological events such as cell migration adhesion and transformation
£226.00
Trichohyalin granules (THG) AE15 Antibody- Mouse Anti-trichohyalin granules (THG) AE15
Trichohyalin is a hair follicle protein with characteristics similar to those of profilaggrin (135940) involucrin (147360) and loricrin (152445) Trichohyalin is incorporated into the IF (intermediate filament)-like structures in the mature cells of the hair follicles inner root sheath Like profilaggrin involucrin and loricrin trichohyalin becomes highly crosslinked by the enzyme transglutaminase The trichohyalin molecule has a mass of approximately 200 kD and consists predominantly of tandem repeats of an approximately 23-amino acid sequence Fietz et al (1992) used a sheep trichohyalin cDNA probe in tritium-labeled in situ hybridization to demonstrate that the human THL gene is located in the region 1q211-q23 probably 1q213 Profilaggrin involucrin and loricrin map to the same area suggesting that the 4 proteins form a novel superfamily of epithelial structural proteins By analysis of human-rodent somatic cell hybrids and fluorescence in situ hybridization Lee et al (1993) confirmed the mapping of THL to 1q21
£183.00
