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MCPH1 (BRIT1) Antibody- Mouse Anti-MCPH1 (BRIT1)
This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome
MCPH1 looks like it might be a useful prognostic indicator in breast cancer associated with BRCA1 inactivation
£226.00
Nestin Antibody- Mouse Anti-Nestin
Nestin is a Class VI intermediate filament expressed in the developing central nervous system (CNS) in early embryonic neuroepithelial stem cells This protein has been widely used as a predominant marker for stem / progenitor cells glioma cells and tumor endothelial cells in the mammalian CNS Furthermore it is a superior angiogenic marker to evaluate neovascularity of endothelial cells in tumor This highly specific antibody to human nestin can aid in characterizing progenitor cells differentiating into distinct lineages in enhancing the therapeutic potential of human neural stem/progenitor cells in the treatment of CNS diseases or injury and in identifying neuroepithelial tumor cells
£183.00
Neurocan Antibody- Mouse Anti-Neurocan
Neurocan is the major soluble chondroitin sulfate proteoglycan in the brain It is thought to play a functional role in axonal growth and guidance and in the establishment of specific neural pathways during embryonic brain development Neurocan expression in the brain is developmentally regulated Early on the major form of neurocan consists of a 245kD core protein with approximately two chondroitin sulfate glycosoaminoglycan chains of 22kD each Later neurocan comprises a 180kD core protein Both forms of neurocan contain only chondroitin 4-sulfate glycosoaminoglycan chains By virtue of their high expression at sites of neural damage and trauma chondroitin sulfate proteoglycans including neurocan are thought to inhibit successful nerve regeneration
£183.00
NeurocanAntibody - Mouse Anti-Neurocan
Neurocan is the major soluble chondroitin sulfate proteoglycan in the brain It is thought to play a functional role in axonal growth and guidance and in the establishment of specific neural pathways during embryonic brain development Neurocan expression in the brain is developmentally regulated Early on the major form of neurocan consists of a 245kD core protein with approximately two chondroitin sulfate glycosoaminoglycan chains of 22kD each Later neurocan comprises a 180kD core protein Both forms of neurocan contain only chondroitin 4-sulfate glycosoaminoglycan chains By virtue of their high expression at sites of neural damage and trauma chondroitin sulfate proteoglycans including neurocan are thought to inhibit successful nerve regeneration
£226.00
Receptor Tyrosine Phosphatase Beta (phosphacan) Antibody- Mouse Anti-Receptor Tyrosine Phosphatase Beta (phosphacan)
PTPRB is a member of the protein tyrosine phosphatase (PTP) family The family comprises at least 37 proteins characterized by a catalytic phosphatase domain of approximately 240 amino acids and includes both transmembrane and cytosolic enzymes PTP1B is a transmembrane PTP The PTPs have high substrate specificity for phosphotyrosyl proteins at the primary sequence level sharing little similarity with the protein serine phosphatases protein threonine phosphatases or the acid and alkaline phosphatases PTP beta interacts with and regulates the tyrosine phosphorylation level of catenins which are critical in physiological and pathological events such as cell migration adhesion and transformation
£183.00
Receptor Tyrosine Phosphatase Beta (phosphacan) Antibody- Mouse Anti-Receptor Tyrosine Phosphatase Beta (phosphacan)
PTPRB is a member of the protein tyrosine phosphatase (PTP) family The family comprises at least 37 proteins characterized by a catalytic phosphatase domain of approximately 240 amino acids and includes both transmembrane and cytosolic enzymes PTP1B is a transmembrane PTP The PTPs have high substrate specificity for phosphotyrosyl proteins at the primary sequence level sharing little similarity with the protein serine phosphatases protein threonine phosphatases or the acid and alkaline phosphatases PTP beta interacts with and regulates the tyrosine phosphorylation level of catenins which are critical in physiological and pathological events such as cell migration adhesion and transformation
£226.00
