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Parkinson’s disease is degenerative neurological disorder caused by the death of dopamine generating cells in the midbrain.

The exact process by which cell death occurs is unknown .It is known that the disease is often associated with the accumulation of the alpha-synuclein protein in cells forming Lewy bodies. It is not known if this is causative response or a protective one. Other cell death mechanisms may be impacted by reduced mitochondrial activity, iron accumulation and oxidative stress.