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Nuclear Envelope Antibodies

Nuclear envelope antibodies relate to the nuclear envelope which is a thin membrane that surrounds the genetic material in eukaryotic cells. It consists of a double layer of lipids, separating the nucleus content, principally DNA, from the surrounding cell cytoplasm.

The outer part of the nuclear envelope membrane is rough endoplasmic reticulum spotted as it is with ribosomes. The inner part consists of flat membrane proteins e.g. Emerin which are linked to the nuclear lamina and mutations in Lamins A and B

These mutations are thought to be linked to laminopathic diseases like Emery Dreifuss muscular dystrophy, limb-girdle muscular dystrophy type 1B, dilated cardiomyopathy with conduction defect, and Charcot-Marie-Tooth disorder type 2B1 which the use of nuclear envelope antibodies reach is indicated

The nuclear envelope is perforated with pores which enable the transport of proteins and RNA between the nucleus and cytoplasm. The inner and outer membrane conjoin at each nuclear pore site.

Nuclear envelope antibodies are available in various quantities including 0.05 ml, 0.1ml, 0.2 ml ,1 ml.

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Immunocytochemistry/ Immunofluorescence - Anti-Emerin antibody at a 1/100 dilution
Primary Description:

Goat Anti-Emerin 

Product Reference Code: IQ323
Species Reactivity:

Mouse, Rat, Hamster, Human

Applications:

WB, ICC/IF

£226.00

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Immunocytochemistry/ Immunofluorescence - Anti-Emerin antibody at a 1/100 dilution
Primary Description:

Sheep Anti-Emerin 

Product Reference Code: IQ324
Species Reactivity:

Mouse, Rat, Hamster

Applications:

WB, ICC/IF, Electron Microscopy

£226.00

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Western blot - Lamin A + C antibody [JoL5] - Nuclear Envelope Marker
Primary Description:

Mouse Anti-Lamin A + C antibody [JoL5] - Nuclear Envelope Marker

Product Reference Code: IQ188
Species Reactivity:

Mouse, Human

Applications:

ICC/IF, WB

£226.00

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Western blot - Lamin A + C antibody [JoL5] - Nuclear Envelope Marker
Primary Description:

Mouse Anti-Lamin A + C antibody [JoL5] - Nuclear Envelope Marker

Product Reference Code: IQ252
Species Reactivity:

Mouse, Human

Applications:

ICC/IF, WB

£183.00

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Immunostaining reaction of lamin A antibody with human epidermis
Primary Description:

Mouse Anti-Lamin A [133A2]

Product Reference Code: IQ248
Species Reactivity:

Mouse, Rat, Cow, Dog, Human, Monkey

Applications:

Flow Cyt, IHC-Fr, WB, IHC-P, ICC/IF, IP

£183.00

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Lamin expression in basal cell skin carcinomas. Frozen sections stained with Lamin A antibody [JOL4]
Primary Description:

Mouse Anti-Lamin A [JOL4]

Product Reference Code: IQ330
Species Reactivity:

Human, Mouse

Applications:

IF, IHC(Fr), IP, WB

£183.00

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Immunohistochemistry of Anti-Lamin A+C on formalin fixed paraffin embedded skin tissue
Primary Description:

Mouse Anti-Lamin A+C [JOL2]

Product Reference Code: IQ332
Species Reactivity:

Human, African Green Monkey

Applications:

ICC/IF, IHC-Fr, IHC-P, WB, IP, Flow Cyt

£199.00

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IHC using Lamin A+C Antibody [JOL2] on fixed human colon
Primary Description:

Mouse Anti-Lamin A+C [JOL2]

Product Reference Code: IQ608
Species Reactivity:

Human, African Green Monkey

Applications:

IP, WB, IHC (P)

£249.00

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IHC using Lamin A+C Antibody [JOL2]: HRP conjugate on fixed human colon
Primary Description:

Mouse Anti-Lamin A+C [JOL2]: Horseradish peroxidase (HRP)

Product Reference Code: IQ608HRP
Species Reactivity:

Human, African Green Monkey

Applications:

IP, WB, IHC (P)

£245.00

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Immunocytochemistry/ Immunofluorescence - Lamin A + C antibody [JoL3] - Nuclear Envelope Marker
Primary Description:

Mouse Anti-Lamin A + C antibody [JoL3] - Nuclear Envelope Marker

Product Reference Code: IQ251
Species Reactivity:

Mouse, Rat, Human

Applications:

WB, ICC/IF

£183.00

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Primary Description:

Mouse Anti-Lamin A+C R453W [12A-2F5]

Product Reference Code: IQ541
Species Reactivity:

Human

Applications:

WB, IP, ICC/IF

£226.00

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Confocal optical section, green is FITC (lamin A/C [JOL3]) and blue is DAPI (DNA). Cells were fixed in 4% paraformaldehyde in PEM buffer then extracted with 0.5% Triton X-100 before labelling with JOL3-FITC.
Primary Description:

Mouse Anti-Lamin A/C [JOL3]: FITC

Product Reference Code: IQ656FITC
Species Reactivity:

Human, Mouse, Rat

Applications:

ICC/IF

£245.00

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Immunocytochemistry - Lamin B1 + B2 antibody [X223] - Nuclear Envelope Marker
Primary Description:

Mouse Anti-Lamin B1 + B2 antibody [X223] - Nuclear Envelope Marker

Product Reference Code: IQ176
Species Reactivity:

Mouse, Rat, Cow, Human

Applications:

ICC/IF, WB 

£226.00

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Immunohistochemistry of lamin B1 antibody [119D5-F1] - Nuclear Envelope Marker on human epidermis
Primary Description:

Mouse Anti-Lamin B1 [119D5-F1] - Nuclear Envelope Marker

Product Reference Code: IQ249
Species Reactivity:

Mouse, Rat, Sheep, Rabbit, Cow, Dog, Human, Zebrafish

Applications:

WB, Dot Blot, ELISA, Flow Cyt, ICC/IF, IHC, IP

£183.00

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Immunostaining reaction of lamin B2 antibody [LN43] with human epidermis
Primary Description:

Mouse Anti-Lamin B2 [LN43] - Nuclear Envelope Marker

Product Reference Code: IQ250
Species Reactivity:

 Mouse, Hamster, Human, Xenopus laevis, Zebrafish

Applications:

ICC/IF, Flow Cyt, IHC-Fr, WB, IP

£183.00

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Immunohistochemistry showing Lamin C on formalin fixed paraffin embedded skin tissue at 1:100
Primary Description:

Rabbit Anti-Lamin C

Product Reference Code: IQ177
Species Reactivity:

Human, Mouse, Rat 

Applications:

ICC/IF, IHC-P, IHC-Fr, WB, Flow

£226.00

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