Nuclear pore complex antibodies are implicated in scientific discovery focused on the large protein complexes, nucleoporins, that cross the nuclear envelope and permit the transport of water soluble molecules, including RNA and ribosome’s moving outbound from the nucleus and proteins , carbohydrates, lipids etc moving inbound into the cell nucleus.
Nuclear pore complex antibodies research aid understanding in distinct disease area's including Triple A syndrome, myeloid leukaemia and certain tumour formation.
Nuclear pore complex antibodies are available in the following volumes including 0.05 ml, 0.1ml, 0.2 ml, 1 ml and 2 ml.
Research Notes on nuclear pore complex antibodies are available
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gp210 (C-terminal) Antibody- Rabbit Anti-gp210 (C-terminal)
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. GP210 is a membrane-spanning glycoprotein that is a major component of the nuclear pore complex, it is an evolutionarily conserved and has early roles in nuclear pore formation and mediates pore dilation with its tail-binding partners
£226.00
gp210 (N-terminal) Antibody- Rabbit Anti-gp210 (N-terminal)
The nuclear pore complex is a massive structure that extends across the nuclear envelope forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells GP210 is a membrane-spanning glycoprotein that is a major component of the nuclear pore complex it is an evolutionarily conserved and has early roles in nuclear pore formation and mediates pore dilation with its tail-binding partners
£226.00
Mad1L1 Antibody- Mouse Anti- Mad1L1
MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate MAD1L1 functions as a homodimer and interacts with MAD2L1 MAD1L1 may play a role in cell cycle control and tumor suppression
£226.00
Mad2p Antibody- Rabbit Anti-Mad2p
MAD2 is a non-essential gene that encodes a component of the spindle checkpoint. The spindle checkpoint delays the onset of anaphase in cells with defects in mitotic spindle assembly or in the attachment of chromosomes to the spindle microtubules. The checkpoint works by inhibiting the activity of the anaphase promoting complex, thereby preventing the degradation of several cell cycle regulators.hMAD2 is the human homologue of yeast MAD2
£226.00
Nup153 Antibody- Sheep Anti-Nup153
Nuclear pore complexes are extremely elaborate structures that mediate the regulated movement of macromolecules between the nucleus and cytoplasm These complexes are composed of at least 100 different polypeptide subunits many of which belong to the nucleoporin family Nucleoporins are pore complex specific glycoproteins characterized by cytoplasmically oriented O linked N acetylglucosamine residues and numerous repeats of the pentapeptide sequence XFXFG Nup153 has three distinct domains a N terminal region within which a pore targeting domain has been identified a central region containing multiple zinc finger motifs and a C terminal region containing multiple XFXFG repeats Nup153 is a possible DNA binding subunit of the nuclear pore complex (NPC) The repeat containing domain may be involved in anchoring components of the pore complex to the pore membrane
£226.00
Nup53 Antibody- Rabbit Anti-Nup53
Nup53 encodes a recently identified nuclear pore protein. Transport of macromolecules between the nucleus and the cytoplasm of eukaryotic cells occurs through the nuclear pore complex (NPC), a large macromolecular complex that spans the nuclear envelope. The yeast NPC shares several features with the vertebrate NPC, despite being smaller and less elaborate. Nup53p forms a complex with two other nucleoporins, Nup170p and Asm4p. The complex is found on both the nuclear and cytoplasmic faces of the NPC, and associates with Pse1p, a member of a protein family implicated in nuclear protein import, via direct interaction between Nup53p and Pse1p. Nup53p is structurally similar to Asm4p, and similar proteins sequences are found in several eukaryotes including human and other multicellular species. Nup53p is not essential; deletion of Nup53 and ASM4 causes slow growth and altered subcellular distribution of Pse1p. In a nup53 pse1 double mutant, NLS-containing proteins are mislocalized to the cytoplasm
£226.00
Ran Antibody- Rabbit Anti-Ran
Ran (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The Ran protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of Ran requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in Ran disrupt DNA synthesis. Because of its many functions, it is likely that Ran interacts with several other proteins. Ran regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. Ran could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of Ran-GTP around chromatin which, in turn, induces the local nucleation of microtubules. Ran is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). Ran coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.
£226.00
