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EAPP Antibody ; Mouse Anti-EAPP
Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis
£226.00
hCAP-D3 Antibody ; Mouse Anti-hCAP-D3
Condensin complexes I and II play essential roles in mitotic chromosome assembly and segregation. Condensins contain 2 invariant structural maintenance of chromosome (SMC) subunits, SMC2 and SMC4. hCAP-D3 is a regulatory non-SMC subunit of the condensin II complex
£226.00
HDAC2 Antibody ; Mouse Anti-HDAC2
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity
£226.00
HDAC3 Antibody ; Mouse Anti-HDAC3
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation
£226.00
RanGEF (RCC1) Antibody- Rabbit Anti-RanGEF
Ran GTPase plays important roles in nucleocytoplasmic transport in interphase and in both spindle formation and nuclear envelope (NE) assembly during mitosis The latter functions rely on the presence of high local concentrations of GTP bound Ran near mitotic chromatin RanGTP localization has been proposed to result from the association of Rans GDP/GTP exchange factor RCC1 with chromatin but Ran is shown here to bind directly to chromatin in two modes either dependent or independent of RCC1 and where bound to increase the affinity of chromatin for NE membranes
£226.00
