Nuclear Signalling RNA Processing

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TAP Antibody- Mouse Anti-TAP (tip associating protein)

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters ABC proteins transport various molecules across extra- and intra-cellular membranes ABC genes are divided into seven distinct subfamilies (ABC1 MDR/TAP MRP ALD OABP GCN20 White) This protein is a member of the MDR/TAP subfamily Members of the MDR/TAP subfamily are involved in multidrug resistance The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble Mutations in this gene may be associated with ankylosing spondylitis insulin-dependent diabetes mellitus and celiac disease

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