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Ran Antibody- Rabbit Anti-Ran
Ran (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The Ran protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of Ran requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in Ran disrupt DNA synthesis. Because of its many functions, it is likely that Ran interacts with several other proteins. Ran regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. Ran could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of Ran-GTP around chromatin which, in turn, induces the local nucleation of microtubules. Ran is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). Ran coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.
£226.00
Ran Antibody- Rabbit Anti-Ran
Ran (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex The Ran protein is also involved in control of DNA synthesis and cell cycle progression Nuclear localization of Ran requires the presence of regulator of chromosome condensation 1 (RCC1) Mutations in Ran disrupt DNA synthesis Because of its many functions it is likely that Ran interacts with several other proteins Ran regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules Ran could be a key signaling molecule regulating microtubule polymerization during mitosis RCC1 generates a high local concentration of Ran-GTP around chromatin which in turn induces the local nucleation of microtubules Ran is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor Polyglutamine repeat expansion in the AR is linked to Kennedys disease (X-linked spinal and bulbar muscular atrophy) Ran coactivation of the AR diminishes with polyglutamine expansion within the AR and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedys disease
£183.00
RanGAP Antibody- Rabbit Anti-RanGAP
Ran is a small signaling GTPase that is involved in nucleocytoplasmic
transport. Two additional functions of animal Ran in the formation of spindle
asters and the reassembly of the nuclear envelope in mitotic cells have been
recently reported. In contrast to Ras or Rho, Ran is not associated with
membranes. Instead, the spatial sequestering of its accessory proteins, the Ran
GTPase-activating protein RanGAP and the nucleotide exchange factor RCC1,
appears to define the local concentration of RanGTP vs. RanGDP involved in
signaling. Mammalian RanGAP is bound to the nuclear pore by a mechanism
involving the attachment of small ubiquitin-related modifier protein (SUMO)
to its C terminus and the subsequent binding of the SUMOylated domain to the
nucleoporin Nup358
£226.00
RanGAPAntibody - Rabbit Anti-RanGAP
Ran is a small signaling GTPase that is involved in nucleocytoplasmic
transport. Two additional functions of animal Ran in the formation of spindle
asters and the reassembly of the nuclear envelope in mitotic cells have been
recently reported. In contrast to Ras or Rho, Ran is not associated with
membranes. Instead, the spatial sequestering of its accessory proteins, the Ran
GTPase-activating protein RanGAP and the nucleotide exchange factor RCC1,
appears to define the local concentration of RanGTP vs. RanGDP involved in
signaling. Mammalian RanGAP is bound to the nuclear pore by a mechanism
involving the attachment of small ubiquitin-related modifier protein (SUMO)
to its C terminus and the subsequent binding of the SUMOylated domain to the
nucleoporin Nup358
£183.00
RanGEF (RCC1) Antibody- Rabbit Anti-RanGEF
Ran GTPase plays important roles in nucleocytoplasmic transport in interphase and in both spindle formation and nuclear envelope (NE) assembly during mitosis The latter functions rely on the presence of high local concentrations of GTP bound Ran near mitotic chromatin RanGTP localization has been proposed to result from the association of Rans GDP/GTP exchange factor RCC1 with chromatin but Ran is shown here to bind directly to chromatin in two modes either dependent or independent of RCC1 and where bound to increase the affinity of chromatin for NE membranes
£226.00
RanGEF (RCC1) Antibody- Rabbit Anti-RanGEF (RCC1)
Ran GTPase plays important roles in nucleocytoplasmic transport in interphase and in both spindle formation and nuclear envelope (NE) assembly during mitosis The latter functions rely on the presence of high local concentrations of GTP bound Ran near mitotic chromatin RanGTP localization has been proposed to result from the association of Rans GDP/GTP exchange factor RCC1 with chromatin but Ran is shown here to bind directly to chromatin in two modes either dependent or independent of RCC1 and where bound to increase the affinity of chromatin for NE membranes
£183.00
Receptor Tyrosine Phosphatase Beta (phosphacan) Antibody- Mouse Anti-Receptor Tyrosine Phosphatase Beta (phosphacan)
PTPRB is a member of the protein tyrosine phosphatase (PTP) family The family comprises at least 37 proteins characterized by a catalytic phosphatase domain of approximately 240 amino acids and includes both transmembrane and cytosolic enzymes PTP1B is a transmembrane PTP The PTPs have high substrate specificity for phosphotyrosyl proteins at the primary sequence level sharing little similarity with the protein serine phosphatases protein threonine phosphatases or the acid and alkaline phosphatases PTP beta interacts with and regulates the tyrosine phosphorylation level of catenins which are critical in physiological and pathological events such as cell migration adhesion and transformation
£183.00
Receptor Tyrosine Phosphatase Beta (phosphacan) Antibody- Mouse Anti-Receptor Tyrosine Phosphatase Beta (phosphacan)
PTPRB is a member of the protein tyrosine phosphatase (PTP) family The family comprises at least 37 proteins characterized by a catalytic phosphatase domain of approximately 240 amino acids and includes both transmembrane and cytosolic enzymes PTP1B is a transmembrane PTP The PTPs have high substrate specificity for phosphotyrosyl proteins at the primary sequence level sharing little similarity with the protein serine phosphatases protein threonine phosphatases or the acid and alkaline phosphatases PTP beta interacts with and regulates the tyrosine phosphorylation level of catenins which are critical in physiological and pathological events such as cell migration adhesion and transformation
£226.00
Retinal S-antigen (arrestin) Antibody- Mouse Anti- Retinal S-antigen
Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated-phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase.
£183.00
Retinal S-antigen (arrestin) Antibody- Mouse Anti- Retinal S-antigen
Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated-phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase
£226.00
RNA polymerase II CTD Antibody- Mouse Anti-RNA polymerase II CTD
RNA polymerase II carboxy-terminal domain (CTD) interacts with a large multisubunit complex that contains TATA-binding protein (TBP) and is an integral part of the transcription initiation complex Phosphorylation of RNA polymerase IIs largest subunit C-terminal domain (CTD) is a key event during mRNA metabolism Numerous enzymes including cell cycle-dependent kinases and TFIIF-dependent phosphatases target the CTD
£183.00
RNA polymerase II CTD Antibody- Mouse Anti-RNA polymerase II CTD-phosphorylated
RNA polymerase II carboxy-terminal domain (CTD) interacts with a large multisubunit complex that contains TATA-binding protein (TBP) and is an integral part of the transcription initiation complex Phosphorylation of RNA polymerase IIs largest subunit C-terminal domain (CTD) is a key event during mRNA metabolism Numerous enzymes including cell cycle-dependent kinases and TFIIF-dependent phosphatases target the CTD
£183.00
SUN2 Antibody- Rabbit Anti-SUN2
SUN proteins form part of the LINC complex - a protein bridge that spans the nuclear envelope linking the nucleoskeleten to the actin cytoskeleten. They are located on the inner nuclear membrane side of the complex. The LINC complex is thought to function in controlling nuclear position, contributing to mechanical resistance and the overall architecture of the cell. SUN2 can exist in a heterodimer with SUN1. Both can interact with lamins and nesprins in the nuclear envelope
£183.00
