Apoptosis from Immuquest

HEF-1 Antibody [2G9]

Wed, 03 Apr 2013 11:23:33 +0100

HEF1 is a multifunctional protein involved in integrin-based signaling that affects cell motility growth apoptosis and oncogenic transformation The Cas family of docking proteins have been the subject of intense research because of their role in cell motility growth apoptosis and oncogenic transformation These proteins are substrates of focal adhesion kinase (FAK) and the Src family of tyrosine kinases two active targets for drug development HEF1 protein production increases levels of mRNA transcripts that encode proteins associated with motility cell transformation and invasiveness including several metalloproteinases MLCK p160ROCK and ErbBi HEF1 overproduction also mediates apoptosis in epithelial-derived cell lines including MCF7 and HeLa cells Recent clinical studies at another institution have found that overexpression of BCAR1 (p130Cas) a related protein is associated with tamoxifen resistance This highlights the importance of studying the role of this family of proteins in cancer prognosis

HEF1 Antibody [2G9]

Wed, 03 Apr 2013 11:18:56 +0100

HEF1 Antibody [2G9]

hnRNP U Antibody [3G6]

Tue, 23 Apr 2013 12:22:42 +0100

hnRNP U Antibody [3G6]

The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA) These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm The hnRNP proteins have distinct nucleic acid binding properties hnRNP U is thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes During apoptosis this protein is cleaved in a caspase-dependent way

Lamin A + C antibody [JoL3] - Nuclear Envelope Marker

Thu, 02 May 2013 10:32:29 +0100

Lamin A + C antibody [JoL3] - Nuclear Envelope Marker

Nuclear Lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane Two main subtypes of nuclear lamins can be distinguished ie A-type Lamins and B-type Lamins The A-type Lamins comprise a set of three proteins arising from the same gene by alternative splicing ie Lamin A Lamin C and Lamin Adel 10 while the B-type Lamins include two proteins arising from two distinct genes ie Lamin B1 and Lamin B2 Recent evidence has revealed that mutations in A-type Lamins give rise to a range of rare but dominant genetic disorders including Emery-Dreifuss muscular dystrophy dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy In addition the expression of A-type Lamins coincides with cell differentiation and as A-type Lamins specifically interact with chromatin a role in the regulation of differential gene expression has been suggested for A-type Lamins

Lamin A + C antibody [JoL5] - Nuclear Envelope Marker

Thu, 02 May 2013 10:57:39 +0100

Lamin A + C antibody [JoL5] - Nuclear Envelope Marker

Thu, 02 May 2013 11:00:10 +0100

Lamin A + C antibody [JoL5] - Nuclear Envelope Marker

Lamin A Antibody [133A2]

Tue, 23 Apr 2013 15:10:37 +0100

Lamin A Antibody [133A2]

Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane Two main subtypes of nuclear lamins can be distinguished ie A type lamins and B type lamins The A type lamins comprise a set of three proteins arising from the same gene by alternative splicing ie lamin A lamin C and lamin Adel 10 while the B type lamins include two proteins arising from two distinct genes ie lamin B1 and lamin B2 Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders including Emery-Dreifuss muscular dystrophy dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy In addition the expression of A type lamins coincides with cell differentiation and as A type lamins specifically interact with chromatin a role in the regulation of differential gene expression has been suggested for A type lamins

Lamin A Antibody [JOL4]

Tue, 23 Apr 2013 14:14:50 +0100

Lamin A Antibody [JOL4]

Tue, 23 Apr 2013 14:31:25 +0100

Lamin A Antibody [JOL4]

Lamin A+C Antibody [JOL2]

Tue, 02 Apr 2013 14:28:51 +0100

Lamin A+C Antibody [JOL2]

Tue, 02 Apr 2013 14:37:14 +0100

Lamin A+C Antibody [JOL2]

Lamin A+C Antibody [JoL3] - Nuclear Envelope Marker

Thu, 02 May 2013 10:32:51 +0100

Lamin A+C Antibody [JoL3] - Nuclear Envelope Marker

Lamin B1 + B2 antibody [X223] - Nuclear Envelope Marker

Thu, 02 May 2013 12:35:02 +0100

Lamin B1 + B2 antibody [X223] - Nuclear Envelope Marker

Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.

Lamin B1 antibody [119D5-F1] - Nuclear Envelope Marker

Thu, 02 May 2013 13:08:59 +0100

Lamin B1 antibody [119D5-F1] - Nuclear Envelope Marker

An important part of the nucleus is formed by nuclear lamina Nuclear lamins form a network of filaments at the nucleoplasmic site of the nuclear membrane Two main subtypes of nuclear lamins can be distinguished ie A type lamins and B type lamins The A type lamins comprise a set of three proteins arising from the same gene by alternative splicing ie lamin A lamin C and lamin Adel10 while the B-type lamins include two proteins arising from two distinct genes ie lamin B1 and lamin B2 The nuclear lamins comprise a unique subclass of the intermediate filament protein family They share a molecular domain organisation with the other intermediate filament proteins in that they are fibrous molecules that have an aminoterminal globular head a central rod of alpha helices and a carboxy terminal globular domain Many biochemical and molecular features of lamins have been studied but their functions remain still largely undetermined One of the functions ascribed to the lamina is the maintenance of the structural integrity of the nucleus Besides interactions with the nuclear membrane and other intermediate filaments lamins interact with the nuclear chromatin Eukaryotic chromatin is organised into loops which are attached to the nuclear matrix This organisation is thought to contribute to compaction of the chromatin and regulation of gene expression Lamins as part of the nuclear matrix may be involved in these processes since chromatin binding sites have been detected in both A and B type lamins

Lamin B2 antibody [LN43] - Nuclear Envelope Marker

Thu, 02 May 2013 13:36:23 +0100

Lamin B2 antibody [LN43] - Nuclear Envelope Marker

An important part of the cell nucleus is formed by nuclear lamina Nuclear lamins form a network of filaments at the nucleoplasmic site of the nuclear membrane Two main subtypes of nuclear lamins can be distinguished ie A-type lamins and B-type lamins The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing ie lamin A lamin C and lamin Adel10 while the B-type lamins include two proteins arising from two distinct genes ie lamin B1 and lamin B2 The nuclear lamins comprise a unique subclass of the intermediate filament protein family They share a molecular domain organisation with the other intermediate filament proteins in that they are fibrous molecules that have an aminoterminal globular head a central rod of a-helices and a carboxyterminal globular domain Many biochemical and molecular features of lamins have been studied but their functions remain still largely undetermined One of the functions ascribed to the lamina is the maintenance of the structural integrity of the nucleus Besides interactions with the nuclear membrane and other intermediate filaments lamins interact with the nuclear chromatin Eukaryotic chromatin is organised into loops which are attached to the nuclear matrix This organisation is thought to contribute to compaction of the chromatin and regulation of gene expression Lamins as part of the nuclear matrix may be involved in these processes since chromatin binding sites have been detected in both A- and B-type lamins

Lamin C Antibody

Thu, 02 May 2013 13:41:21 +0100

Lamin C Antibody

PDE1A Antibody

Mon, 17 Jun 2013 10:54:10 +0100

PDE1A Antibody

Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolytic inactivation of the common intracellular second messengers cyclic adenosine and guanosine 3 5-monophosphate (cAMP and cGMP) Thus these enzymes play a critical role in the regulation of a wide range of physiological processes modulated by cyclic nucleotide signalling PDE1 has three subtypes PDE1A PDE1B and PDE1C PDE1A and PDE1B have higher affinity for cGMP than for cAMP whereas PDE1C has high affinity for both cAMP and cGMP

PDE4B Antibody

Wed, 05 Jun 2013 11:29:32 +0100

PDE4B Antibody

Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolytic inactivation of the common intracellular second messengers cyclic adenosine and guanosine 3 5-monophosphate (cAMP and cGMP) Thus these enzymes play a critical role in the regulation of a wide range of physiological processes modulated by cyclic nucleotide signallingThe PDE4 enzyme belongs to a family of cAMP-dependent PDEs that provide the major means of inactivating the key intracellular second messenger cAMP Four genes (4A 4B 4C and 4D) encode around 20 distinct isoform members of the PDE4 family Each isoform is characterized by a unique N-terminal region

TAP1 Antibody [53H8]

Wed, 12 Jun 2013 12:24:18 +0100

TAP1 Antibody [53H8]

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters ABC proteins transport various molecules across extra- and intra-cellular membranes ABC genes are divided into seven distinct subfamilies (ABC1 MDR/TAP MRP ALD OABP GCN20 White) This protein is a member of the MDR/TAP subfamily Members of the MDR/TAP subfamily are involved in multidrug resistance The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble Mutations in this gene may be associated with ankylosing spondylitis insulin-dependent diabetes mellitus and celiac disease

TAP1 Antibody [53H8]

Wed, 12 Jun 2013 12:31:34 +0100

TAP1 Antibody [53H8]