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Ca19.9 Sialyl Lewis a Antibody - Mouse Anti-Ca19.9 Sialyl Lewis a
Mucin glucoprotein is a sialyl Lewisa structure which is synthesized from type 1 blood group precursor chains and is present in individuals expressing the Lewisa and/or Lewisb blood group antigens. In normal tissues, sialyl Lewisa antigen is present in ductal epithelium of the breast, kidney, salivary gland, and sweat glands. Its expression is greatly enhanced in serum as well as in the majority of tumor cells in gastrointestinal (GI) carcinomas
£226.00
Gemin1/SMN Antibody- Mouse Anti-SMN
This gene is part of a 500 kb inverted duplication on chromosome 5q13 This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region The telomeric and centromeric copies of this gene are nearly identical and encode the same protein However mutations in this gene the telomeric copy are associated with spinal muscular atrophy mutations in the centromeric copy do not lead to disease The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy The critical sequence difference between the two genes is a single nucleotide in exon 7 which is thought to be an exon splice enhancer It is thought that gene conversion events may involve the two genes leading to varying copy numbers of each gene The protein encoded by this gene localizes to both the cytoplasm and the nucleus Within the nucleus the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs) This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN 4 and also interacts with several proteins known to be involved in the biogenesis of snRNPs such as hnRNP U protein and the small nucleolar RNA binding protein Two transcript variants are produced by this gene
£226.00
hnRNP-C1/C2 Antibody- Mouse Anti-hnRNP-C1/C2
The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA) These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm The hnRNP proteins have distinct nucleic acid binding properties hnRNP C1 and C2 are encoded by one gene the two alternatively spliced transcript variants have been described
£183.00
Salmonella typhi Antibody- Mouse Anti- Salmonella typhi
The genus Salmonella is a member of the family Enterobacteriaceae The genus is composed of Gram-negative bacilli that are facultative and flagellated (motile) Salmonellae possess 3 major antigens the H or flagellar antigen (phase 1 2) the O or somatic antigen (part of the LPS moiety) and the Vi or capsular antigen (referred to as K in other Enterobacteriaceae) Salmonella typhi is strictly a human pathogen and is the causative agent of Typhoid fever which is characterized by a sustained fever as high as 40C (104F) profuse sweating gastroenteritis and nonbloody diarrhea
£226.00
Serine Protease Inhibitor 2A (Spi2A) Antibody- Hamster Anti-Serine Protease Inhibitor 2A (Spi2A)
Spi2A is a serine and cysteine protease inhibitor It can inhibit lysosomal papain-like proteases including the cathepsins B G H K L and V It is ineffective against elastase granzyme A granzyme B or caspases 3 8 or 9 Inhibition of cytoplasmic cathepsin B following release from the lysosome may protect cells from apoptosis This may facilitate the survival of progenitor T-cells and the subsequent development of long term memory CD8 T-cells
£183.00
Serine Protease Inhibitor 2A (Spi2A) Antibody- Hamster Anti-Serine Protease Inhibitor 2A (Spi2A)
Spi2A is a serine and cysteine protease inhibitor It can inhibit lysosomal papain-like proteases including the cathepsins B G H K L and V It is ineffective against elastase granzyme A granzyme B or caspases 3 8 or 9 Inhibition of cytoplasmic cathepsin B following release from the lysosome may protect cells from apoptosis This may facilitate the survival of progenitor T-cells and the subsequent development of long term memory CD8 T-cells
£226.00
Serratia marcescens Antibody- Mouse Anti-Serratia marcescens
Serratia marcescens is a species of Gram negative bacteria in the family Enterobacteriaceae It is a broad host range pathogen and is also capable of opportunistic infections of humans Some strains of S marcescens are capable of producing a pigment called prodigiosin which ranges in color from dark red to pale pink S marcescens is a rod shaped motile organism and can grow in temperatures ranging from 5 - 40C Celsius and in pH levels ranging from 5 to 9 S marcescens is involved in hospital-acquired infections particularly in urinary tract and wound infections Serratia species cause 14 of nosocomial bloodstream infections with an associated mortality of 25 in USA Most S marcescens strains are resistant to several antibiotics because of the presence of R factors in plasmids
£226.00
Shigella boydii Antibody- Mouse Anti- Shigella boydii
Shigella boydii is a Gram-negative bacteria of the genus Shigella Like other member of the genus S boydii is a nonmotile non-sporeforming rod-shaped bacteria which can cause dysentery in humans through fecal-oral contamination S boydii is the most genetically-divergent of the Shigella genus
£226.00
Sigma 54 Antibody- Mouse Anti-Sigma 54
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released This sigma factor is responsible for the expression of enzymes involved in arginine catabolism The open complex (sigma-54 and core RNA polymerase) serves as the receptor for the receipt of the melting signal from the remotely bound activator protein glnG(ntrC)
£226.00
Sigma 54 Antibody- Mouse Anti-Sigma 54
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released This sigma factor is responsible for the expression of enzymes involved in arginine catabolism The open complex (sigma-54 and core RNA polymerase) serves as the receptor for the receipt of the melting signal from the remotely bound activator protein glnG(ntrC)
£183.00
SMN (Gemin1) Antibody- Mouse Anti-SMN
This gene is part of a 500 kb inverted duplication on chromosome 5q13 This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region The telomeric and centromeric copies of this gene are nearly identical and encode the same protein However mutations in this gene the telomeric copy are associated with spinal muscular atrophy mutations in the centromeric copy do not lead to disease The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy The critical sequence difference between the two genes is a single nucleotide in exon 7 which is thought to be an exon splice enhancer It is thought that gene conversion events may involve the two genes leading to varying copy numbers of each gene The protein encoded by this gene localizes to both the cytoplasm and the nucleus Within the nucleus the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs) This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN 4 and also interacts with several proteins known to be involved in the biogenesis of snRNPs such as hnRNP U protein and the small nucleolar RNA binding protein Two transcript variants are produced by this gene
£183.00
Staphylococcal enterotoxin B Antibody- Mouse Anti-Staphylococcal enterotoxin B
Staphylococcal enterotoxins represent a group of proteins, which are secreted by Staphylococcus aureus and cause staphylococcal food poisoning syndrome. The illness is characterised by high fever, hypotension, diarrhea, shock, and in some cases death. Their molecular masses range between 27 and 30 kDa. At present, seven enterotoxins are known, namely A, B, C1, C2, C3, D and E. Their amino acid sequences have been determined and it was shown that all are single chain polypeptides containing one disulfide bond formed by two half cystines located in the middle of the polypeptide chain, which form the so called cysteine loop. SEB is an extremely potent activator of T cells, stimulating the production and secretion of various cytokines which mediate many of the toxic effects of SEB
£226.00
Staphylococcal enterotoxin B Antibody- Mouse Anti-Staphylococcal enterotoxin B
Staphylococcal enterotoxins represent a group of proteins, which are secreted by Staphylococcus aureus and cause staphylococcal food poisoning syndrome. The illness is characterised by high fever, hypotension, diarrhea, shock, and in some cases death. Their molecular masses range between 27 and 30 kDa. At present, seven enterotoxins are known, namely A, B, C1, C2, C3, D and E. Their amino acid sequences have been determined and it was shown that all are single chain polypeptides containing one disulfide bond formed by two half cystines located in the middle of the polypeptide chain, which form the so called cysteine loop. SEB is an extremely potent activator of T cells, stimulating the production and secretion of various cytokines which mediate many of the toxic effects of SEB
£226.00
SUN1 Antibody - Rabbit Anti-SUN1
Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs)
£226.00
SUN2 Antibody ; Rabbit Anti-SUN2
SUN proteins form part of the LINC complex - a protein bridge that spans the nuclear envelope linking the nucleoskeleten to the actin cytoskeleten. They are located on the inner nuclear membrane side of the complex. The LINC complex is thought to function in controlling nuclear position, contributing to mechanical resistance and the overall architecture of the cell. SUN2 can exist in a heterodimer with SUN1. Both can interact with lamins and nesprins in the nuclear envelope
£226.00
