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CCR9 Antibody - Rat Anti CCR9 1ml
The protein encoded by this gene is a member of the beta chemokine receptor family It is predicted to be a seven transmembrane protein similar to G protein coupled receptors Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions This gene is expressed in a range of tissues and hemopoietic cells The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors This receptor appears to bind the majority of beta-chemokine family members however its specific function remains unknown The specific ligand of this receptor is CCL25 It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract This gene is mapped to chromosome 3p213 a region that includes a cluster of chemokine receptor genes Two alternatively spliced transcript variants have been described
£226.00
MERTK Antibody- Mouse Anti-Mer Receptor Tyrosine Kinase
In vertebrates the photoreceptor cells are the basic sensory apparatus of the retina primarily converting photon energy absorbed from light into neuronal signals The photoreceptor proximal outer segments are synthesized daily by cell bodies and outer segment tips are removed with a circadian rhythm The shed outer segments are endocytosed by adjacent retinal pigment epithelial (RPE) cells and are recycled to photoreceptors The receptor tyrosine kinase MERTK protein is an approximately 120-122 kDa (994 amino acids) protein expressed in RPEs MERTK has a tyrosine kinase domain close to the C-terminal region and putative phosphorylation sites Mutation of MERTK in the Royal College of Surgeons (RCS) rat results in defective phagocytosis of photoreceptor outer segments by the retinal pigment epithelium (RPE) and retinal degeneration resulting in retinitis pigmentosa
£226.00
Progesterone Receptor Antibody- Phospho (Ser162) - Mouse Anti- Progesterone Receptor - Phospho (Ser162)
Progesterone plays a central role in the reproductive events associated with the establishment and maintenance of pregnancy Progesterone receptor a member of the steroid receptor superfamily mediates the physiologic effects of progesterone The PGR gene uses separate promoters and translational start sites to produce 2 isoforms PRA and PRB which are identical except for an additional 165 amino acids present only in the N terminus of PRB Although PRA and PRB share several structural domains they are distinct transcription factors that mediate their own response genes and physiologic effects with little overlap
£183.00
T cell receptor Alpha + Beta Antibody- Mouse Anti-T cell receptor Alpha + Beta
The receptors on T cells consist of immunoglobulin like integral membrane glycoproteins containing 2 polypeptide subunits alpha and beta of similar molecular weight 40 to 55 kD in the human Like the immunoglobulins of the B cells each T cell receptor subunit has external to the cell membrane an N terminal variable domain and a C terminal constant domain T cell receptors recognise foreign antigens which have been processed as small peptides and bound to major histocompatibility complex molecules at the surface of antigen presenting cells Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain In a single cell the T cell receptor loci are rearranged and expressed in the order delta gamma beta and alpha If both delta and gamma rearrangements produce functional chains the cell expresses delta and gamma If not the cell proceeds to rearrange the beta and alpha loci
£226.00
