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Acetylated Lysine Antibody - Mouse Anti-Acetylated Lysine 0.1ml
CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation including c-jun and the adenoviral oncoprotein E1A The protein encoded by this gene associates with p300/CBP It has in vitro and in vivo binding activity with CBP and p300 and competes with E1A for binding sites in p300/CBP It has histone acetyl transferase activity with core histones and nucleosome core particles indicating that this protein plays a direct role in transcriptional regulation
£226.00
Acetylated Lysine Antibody - Mouse Anti-Acetylated Lysine 50ul
CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation including c-jun and the adenoviral oncoprotein E1A The protein encoded by this gene associates with p300/CBP It has in vitro and in vivo binding activity with CBP and p300 and competes with E1A for binding sites in p300/CBP It has histone acetyl transferase activity with core histones and nucleosome core particles indicating that this protein plays a direct role in transcriptional regulation
£183.00
APPL1 Antibody - Rabbit Anti-APPL1 50ul
The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation and in the crosstalk between the adiponectin signalling and insulin signalling pathways The encoded protein binds many other proteins including RAB5A DCC AKT2 PIK3CA adiponectin receptors and proteins of the NuRD/MeCP1 complex This protein is found associated with endosomal membranes but can be released by EGF and translocated to the nucleus
£226.00
Histone H4 Me3K20 Antibody ; Mouse Anti-Histone H4 Me3K20
Histone proteins H3, H4, H2A, and H2B function as building blocks to package eukaryotic DNA into repeating nucleosome units that are folded in higher order chromatin fibers. The nucleosome is composed of an octamer containing a H3/H4 tetramer and two H2A/H2B dimers, surrounded by approximately 146 base pairs of DNA. A diverse and elaborate array of post-translational modifications including acetylation, phosphorylation, methylation, ubiquitination, and ADP-ribosylation occurs on the N-terminal tail domains of histones.
Methylation of position-specific lysine residues in histone N termini is a central modification for regulating epigenetic transitions in chromatin. Each methylatable lysine residue can exist in a mono, di, or tri methylated state. Arginine resdiues can also by mono or di methylated
£226.00
OVCA1 Antibody- Rabbit Anti-OVCA1
Chromosome 17 is a hotspot for chromosomal aberrations in breast and ovarian cancer. Candidate oncogenes and tumor suppressors located on this chromosome include OVCA1 and OVCA2, p53, BRCA1, HER2/neu and others. OVCA1 and 2 map to a highly conserved region on human chromosome 17p13.3 that is deleted in 80% of ovarian cancers and shows frequent loss of heterozygosity in breast cancers . OVCA1 is induced by BRCA1 and is closely linked to p53, a well-known tumor suppressor gene. The close linkage of OVCA1 and p53 suggests that coordinated loss of the two genes may lead to ovarian, breast and other tumor types
£226.00
OVCA1 Antibody- Rabbit Anti-OVCA1
Chromosome 17 is a hotspot for chromosomal aberrations in breast and ovarian cancer. Candidate oncogenes and tumor suppressors located on this chromosome include OVCA1 and OVCA2, p53, BRCA1, HER2/neu and others. OVCA1 and 2 map to a highly conserved region on human chromosome 17p13.3 that is deleted in 80% of ovarian cancers and shows frequent loss of heterozygosity in breast cancers . OVCA1 is induced by BRCA1 and is closely linked to p53, a well-known tumor suppressor gene. The close linkage of OVCA1 and p53 suggests that coordinated loss of the two genes may lead to ovarian, breast and other tumor types
£183.00
OVCA2 Antibody- Rabbit Anti-OVCA2
Chromosome 17 is a hotspot for chromosomal aberrations in breast and ovarian cancer. Candidate oncogenes and tumor suppressors located on this chromosome include OVCA1 and OVCA2, p53, BRCA1, HER2/neu and others. OVCA1 and 2 map to a highly conserved region on human chromosome 17p13.3 that is deleted in 80% of ovarian cancers and shows frequent loss of heterozygosity in breast cancers . OVCA1 is induced by BRCA1 and is closely linked to p53, a well-known tumor suppressor gene. The close linkage of OVCA1 and p53 suggests that coordinated loss of the two genes may lead to ovarian, breast and other tumor types
£226.00
RNA polymerase II CTD Antibody- Mouse Anti-RNA polymerase II CTD
RNA polymerase II carboxy-terminal domain (CTD) interacts with a large multisubunit complex that contains TATA-binding protein (TBP) and is an integral part of the transcription initiation complex Phosphorylation of RNA polymerase IIs largest subunit C-terminal domain (CTD) is a key event during mRNA metabolism Numerous enzymes including cell cycle-dependent kinases and TFIIF-dependent phosphatases target the CTD
£183.00
RNA polymerase II CTD Antibody- Mouse Anti-RNA polymerase II CTD-phosphorylated
RNA polymerase II carboxy-terminal domain (CTD) interacts with a large multisubunit complex that contains TATA-binding protein (TBP) and is an integral part of the transcription initiation complex Phosphorylation of RNA polymerase IIs largest subunit C-terminal domain (CTD) is a key event during mRNA metabolism Numerous enzymes including cell cycle-dependent kinases and TFIIF-dependent phosphatases target the CTD
£183.00
Sigma 54 Antibody- Mouse Anti-Sigma 54
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released This sigma factor is responsible for the expression of enzymes involved in arginine catabolism The open complex (sigma-54 and core RNA polymerase) serves as the receptor for the receipt of the melting signal from the remotely bound activator protein glnG(ntrC)
£226.00
Sigma 54 Antibody- Mouse Anti-Sigma 54
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released This sigma factor is responsible for the expression of enzymes involved in arginine catabolism The open complex (sigma-54 and core RNA polymerase) serves as the receptor for the receipt of the melting signal from the remotely bound activator protein glnG(ntrC)
£183.00
TRF1 Antibody- Mouse Anti-TRF1
The TRF1 gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex It is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase acting in cis to limit the elongation of individual chromosome ends The protein structure contains a C-terminal Myb motif a dimerization domain near its N-terminus and an acidic N-terminus Two transcripts of this gene are alternatively spliced products
£183.00
