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Transcription Chromatin

Chromatin is DNA and proteins combined together that make up the contents of the cell. Chromatin ensures DNA fits into the cell and is implicated in cell division, DNA replication and gene expression.

Whilst that complexity and the involvement of DNA damage and epigenetic modifications are no doubt linked it is also the case that chromatin defects (the cellular structure packaging the combination of DNA and proteins) plays a key role in ageing.

A key research question is how these processes are linked? Is it that DNA damage leads to chromatin defects? Or that changes in chromatic structures< impacts DNA replication? Most recently it is hypothesized that DNA damage, epigenetic processes and chromatin aberration are more of network of interlinked processes and that a more straight linear explanation may be too simplistic.

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Indirect Elisa showing activity of Anti-Acetylated Lysine, clone 7F8
Primary Description:

Mouse Anti-Acetyl Lysine [7F8]

Product Reference Code: IQ354
Species Reactivity:

Chicken, Bovine

Applications:

ELISA, WB

£183.00

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Mouse cortical glia stained with anti-APPL1 Antibody (red) and Hoechst (blue)
Primary Description:

Rabbit Anti-APPL1

Product Reference Code: IQ350
Species Reactivity:

Mouse, Rat, Human

Applications:

IP, WB, ICC/IF, IHC-P

£226.00

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immunofluorescence image showing COS cells stained with BRIT1 Antibody [AB11] expressing GFP microcephalin
Primary Description:

Mouse Anti-BRIT1 [AB11]

Product Reference Code: IQ539
Species Reactivity:

Human

Applications:

WB, ICC/IF, ELISA, IP

£226.00

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Primary Description:

Mouse Anti-Histone H4 (tri methyl K20) [6F8-D9]

Product Reference Code: IQ558
Species Reactivity:

Human, Caenorhabditis elegans. Predicted to work with: Xenopus laevis, Arabidopsis thaliana, Fruit fly (Drosophila melanogaster), all Mammals

Applications:

Dot blot, WB against endogenous protein, ELISA, ChIP

£226.00

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Immunoblot analysis of semi-purified HIV-1 virions using clone IN-2 AT 1:2000
Primary Description:

Mouse Anti-HIV1 integrase [IN2]

Product Reference Code: IQ369
Applications:

WB, ICC/IF, IP

£226.00

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-hnRNP U antibody [3G6] staining hnRNPU in human cerebellum
Primary Description:

Mouse Anti-hnRNP U [3G6]

Product Reference Code: IQ210
Species Reactivity:

Mouse, Human, Monkey. Does not react with Chicken, Lizard

Applications:

ELISA, WB, IP, ICC/IF, IHC-P, Flow Cyt, ChIP

£226.00

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Immunostaining reaction of lamin A antibody with human epidermis
Primary Description:

Mouse Anti-Lamin A [133A2]

Product Reference Code: IQ248
Species Reactivity:

Mouse, Rat, Cow, Dog, Human, Monkey

Applications:

Flow Cyt, IHC-Fr, WB, IHC-P, ICC/IF, IP

£183.00

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Lamin expression in basal cell skin carcinomas. Frozen sections stained with Lamin A antibody [JOL4]
Primary Description:

Mouse Anti-Lamin A [JOL4]

Product Reference Code: IQ330
Species Reactivity:

Human, Mouse

Applications:

IF, IHC(Fr), IP, WB

£183.00

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Immunostaining reaction of lamin B2 antibody [LN43] with human epidermis
Primary Description:

Mouse Anti-Lamin B2 [LN43] - Nuclear Envelope Marker

Product Reference Code: IQ250
Species Reactivity:

 Mouse, Hamster, Human, Xenopus laevis, Zebrafish

Applications:

ICC/IF, Flow Cyt, IHC-Fr, WB, IP

£183.00

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Immunohistochemistry showing Lamin C on formalin fixed paraffin embedded skin tissue at 1:100
Primary Description:

Rabbit Anti-Lamin C

Product Reference Code: IQ177
Species Reactivity:

Human, Mouse, Rat 

Applications:

ICC/IF, IHC-P, IHC-Fr, WB, Flow

£226.00

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Primary Description:

Rabbit Anti-LAP2 alpha

Product Reference Code: IQ175
Species Reactivity:

Mouse, Rat, Human

Applications:

ChIP, IP, ICC/IF, WB

£226.00

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Immunocytochemistry/ Immunofluorescence-PABP antibody [10E10] stained HeLa cells
Primary Description:

Mouse Anti-PABP [10E10]

Product Reference Code: IQ216
Species Reactivity:

Rabbit, Chicken, Human, Xenopus laevis, Hamster

Applications:

ELISA, WB, IP, ICC/IF, Flow Cyt

£226.00

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Immunocytochemistry/ Immunofluorescence-PABP antibody [10E10] stained HeLa cells
Primary Description:

Mouse Anti-PABP [10E10]

Product Reference Code: IQ272
Species Reactivity:

Rabbit, Chicken, Human, Xenopus laevis, Hamster

Applications:

ELISA, WB, IP, ICC/IF, Flow Cyt

£183.00

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Western blot - PARP2 antibody
Primary Description:

Goat Anti-PARP2

Product Reference Code: IQ547
Species Reactivity:

Human 

Applications:

WB, ELISA

£226.00

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Western blot - Ran antibody at a 1/500 dilution staining approximately 26kDa Ran in Xenopus egg extract (lane X, 50µg per lane) and HeLa total cell extract (lane Hu, 50µg per lane)
Primary Description:

Rabbit Anti-Ran

Product Reference Code: IQ245
Species Reactivity:

Human, Xenopus laevis

Applications:

IHC-P, ICC/IF, IP, WB

£183.00

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Immunohistochemistry of RCC1 on formalin fixed paraffin embedded skin tissue at 1:100
Primary Description:

Rabbit Anti-RCC1

Product Reference Code: IQ247
Species Reactivity:

Human, Xenopus laevis

Applications:

IHC-P, IP, ICC/IF, WB

£183.00

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