Many RNA’s are the key to modifying other RNA’s. Introns (a nucleotide sequence that is removed by a process of RNA splicing to generate mature RNA) are spliced out of the RNA precursor pre-mRNA. This process is important for the correct translation of the genome.
The modification of the pre mRNA is underpinned by three main processes. Firstly 5’ Capping, the addition of a m7G molecule to the 5 end. Secondly by Polyadenylation, the formation of the Poly tail structure and finally Splicing, the removal of non-coding segments of the pre RNA structure.
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Gemin1/SMN Antibody- Mouse Anti-SMN
This gene is part of a 500 kb inverted duplication on chromosome 5q13 This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region The telomeric and centromeric copies of this gene are nearly identical and encode the same protein However mutations in this gene the telomeric copy are associated with spinal muscular atrophy mutations in the centromeric copy do not lead to disease The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy The critical sequence difference between the two genes is a single nucleotide in exon 7 which is thought to be an exon splice enhancer It is thought that gene conversion events may involve the two genes leading to varying copy numbers of each gene The protein encoded by this gene localizes to both the cytoplasm and the nucleus Within the nucleus the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs) This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN 4 and also interacts with several proteins known to be involved in the biogenesis of snRNPs such as hnRNP U protein and the small nucleolar RNA binding protein Two transcript variants are produced by this gene
£226.00
TAP Antibody- Mouse Anti-TAP (tip associating protein)
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters ABC proteins transport various molecules across extra- and intra-cellular membranes ABC genes are divided into seven distinct subfamilies (ABC1 MDR/TAP MRP ALD OABP GCN20 White) This protein is a member of the MDR/TAP subfamily Members of the MDR/TAP subfamily are involved in multidrug resistance The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble Mutations in this gene may be associated with ankylosing spondylitis insulin-dependent diabetes mellitus and celiac disease
£226.00
Y14 Antibody- Mouse Anti-Y14
Y14 is a protein with a conserved RNA-binding motif It is preferentially associated with mRNAs produced by splicing including both nuclear mRNAs and newly exported cytoplasmic mRNAs It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present thus coupling pre- and post-mRNA splicing events Previously it was thought that two genes encode this protein RBM8A and RBM8B it is now thought that the RBM8B locus is a pseudogene Two alternative start codons result in two forms of the protein and this gene also uses multiple polyadenylation sites
£183.00
