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Acetylated Lysine Antibody - Mouse Anti-Acetylated Lysine 0.1ml
CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation including c-jun and the adenoviral oncoprotein E1A The protein encoded by this gene associates with p300/CBP It has in vitro and in vivo binding activity with CBP and p300 and competes with E1A for binding sites in p300/CBP It has histone acetyl transferase activity with core histones and nucleosome core particles indicating that this protein plays a direct role in transcriptional regulation
£226.00
Acetylated Lysine Antibody - Mouse Anti-Acetylated Lysine 50ul
CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation including c-jun and the adenoviral oncoprotein E1A The protein encoded by this gene associates with p300/CBP It has in vitro and in vivo binding activity with CBP and p300 and competes with E1A for binding sites in p300/CBP It has histone acetyl transferase activity with core histones and nucleosome core particles indicating that this protein plays a direct role in transcriptional regulation
£183.00
ALY Antibody - Mouse Anti-ALY 0.1ml
The protein encoded by this gene is a heat stable nuclear protein and functions as a molecular chaperone It is thought to regulate dimerization DNA binding and transcriptional activity of basic region-leucine zipper (bZIP) proteins
£226.00
ALY Antibody - Mouse Anti-ALY 50ul
The protein encoded by this gene is a heat stable nuclear protein and functions as a molecular chaperone It is thought to regulate dimerization DNA binding and transcriptional activity of basic region-leucine zipper (bZIP) proteins
£183.00
APPL1 Antibody - Rabbit Anti-APPL1 50ul
The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation and in the crosstalk between the adiponectin signalling and insulin signalling pathways The encoded protein binds many other proteins including RAB5A DCC AKT2 PIK3CA adiponectin receptors and proteins of the NuRD/MeCP1 complex This protein is found associated with endosomal membranes but can be released by EGF and translocated to the nucleus
£226.00
Aurora B Antibody - Sheep Anti- Aurora B 0.2ml
Aurora B is a mitotic protein kinase that phosphorylates histone H3 (probably on Serine 10) behaves as a chromosomal passenger protein and may regulate several stages of mitosis such as centrosome separation chromosome segregation and cytokinesis It localizes to the inner centromere region from prophase to anaphase
£226.00
BUB1 Antibody - Mouse (monoclonal) Anti-BUB1 0.1ml
Bub1 is a kinase involved in spindle checkpoint function The kinase functions in part by phosphorylating a member of the miotic checkpoint complex and activating the spindle checkpoint Mutations in Bub1 have been associated with aneuploidy and several forms of cancer
£226.00
BUB1 Antibody - Mouse Anti-BUB1 50ul
Bub1 is a kinase involved in spindle checkpoint function The kinase functions in part by phosphorylating a member of the miotic checkpoint complex and activating the spindle checkpoint Mutations in Bub1 have been associated with aneuploidy and several forms of cancer
£183.00
Cathelicidin antimicrobial peptide Antibody - Mouse Anti-human neutrophil CAP-18 0.1ml
Cathelicidin antimicrobial protein is an antimicrobial protein found in specific granules of polymorphonuclear leukocytes (PMNs)
£226.00
CENP-E Antibody - Mouse Anti-CENP-E 0.1ml
CENPE is a 250-300 kDa human centromere-associated kinesin-like motor protein that accumulates in G2 phase In contrast to other centromere proteins CENPE is not detected at centromeres during interphase and first appears at the centromere region of chromosomes during prometaphase CENPE function is required for the transition from metaphase to anaphase CENPE is probably one of the motors responsible for mammalian chromosome movement and/or spindle elongation
£226.00
CENP-E Antibody - Mouse Anti-CENP-E 50ul
CENPE is a 250-300 kDa human centromere-associated kinesin-like motor protein that accumulates in G2 phase In contrast to other centromere proteins CENPE is not detected at centromeres during interphase and first appears at the centromere region of chromosomes during prometaphase CENPE function is required for the transition from metaphase to anaphase CENPE is probably one of the motors responsible for mammalian chromosome movement and/or spindle elongation
£183.00
Eme1 (Msm4) Antibody- Mouse Anti-Eme1 (Msm4)
EME1 complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein (MUS81) to form an endonuclease complex which cleaves branched DNA structures, especially those arising during stalled DNA replication. The protein may be involved in repairing DNA damage and in maintaining genomic stability. It interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. Alternative splicing results in multiple transcript variants.
£183.00
Emerin Antibody - Mouse Anti-Emerin
Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C
£226.00
EPCAM; CD326 Antibody- Rat Anti-EPCAM
Epithelial Cell Adhesion Molecule (EpCAM) is a 40 kDa cell surface antigen. This antigen has been identified independently by a number of groups, and has been known by a variety of names. Several monoclonal antibodies have been raised against EpCAM, many of which have been described as tumour specific molecules on carcinomas. EpCAM is a Type 1 transmembrane glycoprotein. It is expressed on the basolateral membrane of cells by the majority of epithelial tissues, with the exception of adult squamous epithelium and some specific epithelial cell types including hepatocytes and gastric epithelial cells. EpCAM expression has been reported to be a possible marker of early malignancy, with expression being increased in tumour cells, and de novo expression being seen in dysplastic squamous epithelium
£226.00
FMR1 (Drosophila) Antibody- Mouse (monoclonal) Anti-FMR1
Fragile X syndrome is the most common inherited form of mental retardation It is caused by loss of FMR1 gene activity due to either lack of expression or expression of a mutant form of the protein In mammals FMR1 is a member of a small protein family that consists of FMR1 FXR1 and FXR2 All three members bind RNA and contain sequence motifs that are commonly found in RNA-binding proteins including two KH domains and an RGG boxThe Drosophila genome contains a single gene homologous to the FXR family dFMR1 is subjected to transcriptional and posttranscriptional regulation during development and it homomerizes like its human counterpart dFMR1 profile of expression recapitulates that of the human FXR protein family it is highly enriched in muscles in central nervous system and in gonads In the larval brain anti-dFMR1 also recognizes mushroom bodies a centre that mediates learning and memory These features make the fly an ideal system to analyse the role of the FXR family and to identify genes in the FMRP pathway
£226.00
FMR1 (Drosophila) Antibody- Mouse Anti-FMR1 (Drosophila)
Fragile X syndrome is the most common inherited form of mental retardation It is caused by loss of FMR1 gene activity due to either lack of expression or expression of a mutant form of the protein In mammals FMR1 is a member of a small protein family that consists of FMR1 FXR1 and FXR2 All three members bind RNA and contain sequence motifs that are commonly found in RNA-binding proteins including two KH domains and an RGG boxThe Drosophila genome contains a single gene homologous to the FXR family dFMR1 is subjected to transcriptional and posttranscriptional regulation during development and it homomerizes like its human counterpart dFMR1 profile of expression recapitulates that of the human FXR protein family it is highly enriched in muscles in central nervous system and in gonads In the larval brain anti-dFMR1 also recognizes mushroom bodies a centre that mediates learning and memory These features make the fly an ideal system to analyse the role of the FXR family and to identify genes in the FMRP pathway
£226.00
